“Unlike RNA viruses, the genome of DNA viruses is already a potential substrate for host genome integration, without the need for prior processing. In general, the genome of DNA viruses is translocated to the nucleus, where it remains as an episome to ensure viral persistence. However, the genome of some DNA viruses can be found inserted in the host genome. The mechanisms underlying these integration events, incidental or non-incidental, are still poorly characterized, and the potential advantages for these DNA viruses to integrate are still obscure. Understanding these mechanisms should help elucidate the role of DNA virus integration in the viral life cycle. This section will summarize the current knowledge on integration of some prototypic DNA viruses as well as highlighting some mechanisms involved in this process.”
As you can see, entry of DNA into the nucleus does not necessarily equate to host cell integration of a transgene. In order for gene integration in a controlled fashion, multiple additional steps of DNA processing are required. Random DNA integration is of course always possible.
From my understanding, nowhere in the artical posted by OP does it say that the DNA is integrating into the host genes.
That doesn’t mean it’s not happening. These vaccines are seriously alarming and I would not be surprised if they were integrating into the host genes. All I’m saying is that this article does not directly address integration as far as I can tell.
To further help you out, here’s a good summary paper.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120651/#Sec7title
“Unlike RNA viruses, the genome of DNA viruses is already a potential substrate for host genome integration, without the need for prior processing. In general, the genome of DNA viruses is translocated to the nucleus, where it remains as an episome to ensure viral persistence. However, the genome of some DNA viruses can be found inserted in the host genome. The mechanisms underlying these integration events, incidental or non-incidental, are still poorly characterized, and the potential advantages for these DNA viruses to integrate are still obscure. Understanding these mechanisms should help elucidate the role of DNA virus integration in the viral life cycle. This section will summarize the current knowledge on integration of some prototypic DNA viruses as well as highlighting some mechanisms involved in this process.”
As you can see, entry of DNA into the nucleus does not necessarily equate to host cell integration of a transgene. In order for gene integration in a controlled fashion, multiple additional steps of DNA processing are required. Random DNA integration is of course always possible.
From my understanding, nowhere in the artical posted by OP does it say that the DNA is integrating into the host genes.
That doesn’t mean it’s not happening. These vaccines are seriously alarming and I would not be surprised if they were integrating into the host genes. All I’m saying is that this article does not directly address integration as far as I can tell.
This is literally the focus of the entire study. Lol.