I'm no expert or biochem guy so I'll do my best with their lingo.
Polymerase Chain Reaction (PCR as in PCR testing for "diagnosing covid") is a DNA copy machine.
So I assume when they say
2/8- It demonstrates through elegant structl & biochem expmts what was observed with seq alignements (below): Large genome RNA virus RNA polymerases (eg. CoVs) evolved an active site adapted to increase speed yet maintain fidelity
They mean it in a way of replicating/evolving faster while still remaining stable organism.
3/8- It makes a clear connection between active site evolution of small genome RNA viruses (eg., enteroviruses) towards large genome RNA viruses (eg., CoVs). Swapping key active site residues confers the required properties to expand and maintain large RNA genomes.
So they are saying that this research gives clear insight into the areas that viruses actively evolve frrom including RNA ones like Coronaviruses (SARS-Cov-2 is one).
4/8- This work expands the seminal discoveries (12 years ago !) of the @PeersenLab about the specific fidelity check of viral RNA polymerases, which is totally different from that of DNA polymerases. A MUST read...
Apparently it expands research on evolutionary stability whereas prior research with RNA was only concerned with DNA
Tldr translation please?
I'm no expert or biochem guy so I'll do my best with their lingo.
Polymerase Chain Reaction (PCR as in PCR testing for "diagnosing covid") is a DNA copy machine.
So I assume when they say
They mean it in a way of replicating/evolving faster while still remaining stable organism.
So they are saying that this research gives clear insight into the areas that viruses actively evolve frrom including RNA ones like Coronaviruses (SARS-Cov-2 is one).
Apparently it expands research on evolutionary stability whereas prior research with RNA was only concerned with DNA
Very good, thank you!