As someone who has given TPA many times, it’s not a supplement. It’s an emergency medicine. It’s so potent I’ve seen people starting vomiting frank blood shortly after the infusion starts because they had an undiagnosed GI bleed. Anyways, if given too late after a stroke has occurred, the damaged tissue and vessels in the area are weak and can rupture and with TPA on board it can cause a massive hemorrhagic stroke. There’s a very specific window for it and even with meeting all the requirements I think 4% of people die from receiving it.