The paper was published to the journal, Circulation, and therefore also PubMed, 4 days ago. It affirms that spike proteins are indeed circulating in the blood past vaccination however it qualifies that "vaccination" is still beneficial because covid infection is still worse than the "vaccination".
Affiliations, funding, and conflicts of interest can be found on page 9:
Affiliations Mucosal Immunology and Biology Research Center (L.M.Y., M.D.B., A.K., B.P.B., J.P.D., M.L., A.F.), Department of Pediatrics (L.M.Y., M.D.B., A.K., B.P.B., J.P.D., M.L., D.B., M.L.-R., A.F.), Division of Maternal-Fetal Medicine, Department of Obstet-rics and Gynecology (A.G.E.), Vincent Center for Reproductive Biology (A.G.E.), and Department of Medicine (B.J.), Division of Infectious Disease, Massachu-setts General Hospital, Boston. Harvard Medical School, Boston, MA (L.M.Y., Z.S., Y.C.B., B.P.B., T.N., Y.S., C.-A.C., J.C., A.D., D.B., M.L.-R., B.J., A.G.R., G.A., A.F., D.R.W.). Department of Pathology, Brigham and Women’s Hospital, Boston, MA (Z.S., Y.S., C.-A.C., D.R.W.). Wyss Institute for Biologically Inspired Engineer-ing, Harvard University, Boston, MA (Z.S., Y.S., C.-A.C., D.R.W.). Ragon Institute of MGH, MIT and Harvard, Cambridge, MA (Y.C.B., E.B., B.J., G.A.). Department of Anesthesiology, Critical Care and Pain Medicine (T.N., A.G.R.), Department of Pediatrics, Division of Immunology (J.C.), and Department of Cardiology (A.D.), Boston Children’s Hospital, MA. Department of Pediatrics, Division of Infectious Diseases and Immunology, Infectious and Immunologic Diseases Research Cen-ter, and Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA (M.A.).
Sources of FundingThis research was supported by the National Institutes of Health: National Heart, Lung, and Blood Institute (5K08HL143183 to Dr Yonker), the National Insti-tute of Diabetes and Digestive and Kidney Diseases (DK104344 to Dr Fasano), National Institute of Child Health and Human Development (R01HD100022-02S2 to Dr Edlow), and National Institute of Allergy and Infectious Diseases (3R01AI072726-10S1 to Dr Arditi; 3R37AI080289-11S1, R01AI146785 and U19AI42790-01, U19AI135995-02, 1U01CA260476-01, and CIV-IC75N93019C00052 to Dr Alter). They also report funding from the Regione Campania Italy (CUP G58D20000240002-SURF 20004BP000000011 to Dr Fasano), Boston Children’s Hospital’s Taking on COVID-19 Together Study (to Dr Randolph), and MassGeneral for Children (to Dr Yonker). Funding for the SARS-CoV-2 antigen measurements came from a generous donation from Bar-bara and Amos Hostetter and the Chleck Foundation. The authors thank Nancy Zimmerman, Mark and Lisa Schwartz, an anonymous donor (financial support), Terry and Susan Ragon, and the Samana Cay Massachusetts General Hospi-tal Research Scholars award for their support. They acknowledge support from the Massachusetts Consortium on Pathogen Readiness, the Musk Foundation, and the Gates Foundation Global Health Vaccine Accelerator Platform funding (OPP1146996 and INV-001650).
DisclosuresDr Walt has a financial interest in Quanterix Corp, a company that develops an ultrasensitive digital immunoassay platform. He is an inventor of the single-molecule array technology, is a founder of the company, and serves on its board of directors. Dr Walt’s interests were reviewed and are managed by Brigham and Women’s Hospital and MassGeneral Brigham in accordance with conflict of interest policies. Dr Alter has been employed by Moderna since October 2022; her contributions to this article preceded her employment by Moderna. Dr Alter is also a founder and equity holder of Seromyx Systems, a company de-veloping a platform technology to profile antibody immunity. Drs Julg and Alter are employees and equity holders of Leyden Labs, a company developing pan-demic prevention therapeutics. Their interests were reviewed and are managed by Massachusetts General Hospital and MassGeneral Brigham in accordance with their conflict of interest policies. Dr Randolph received funding (to Boston Children’s Hospital) from the US Centers for Disease Control and Prevention to study COVID-19 complications in children outside of this work. The other authors report no conflicts.
I guess they want to know how well their vax is doing in the wild. They need to monitor their creation.
The paper was published to the journal, Circulation, and therefore also PubMed, 4 days ago. It affirms that spike proteins are indeed circulating in the blood past vaccination however it qualifies that "vaccination" is still beneficial because covid infection is still worse than the "vaccination".
Full text article: https://www.ahajournals.org/doi/epdf/10.1161/CIRCULATIONAHA.122.061025
Links: https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.061025 https://pubmed.ncbi.nlm.nih.gov/36597886/
Affiliations, funding, and conflicts of interest can be found on page 9:
Affiliations Mucosal Immunology and Biology Research Center (L.M.Y., M.D.B., A.K., B.P.B., J.P.D., M.L., A.F.), Department of Pediatrics (L.M.Y., M.D.B., A.K., B.P.B., J.P.D., M.L., D.B., M.L.-R., A.F.), Division of Maternal-Fetal Medicine, Department of Obstet-rics and Gynecology (A.G.E.), Vincent Center for Reproductive Biology (A.G.E.), and Department of Medicine (B.J.), Division of Infectious Disease, Massachu-setts General Hospital, Boston. Harvard Medical School, Boston, MA (L.M.Y., Z.S., Y.C.B., B.P.B., T.N., Y.S., C.-A.C., J.C., A.D., D.B., M.L.-R., B.J., A.G.R., G.A., A.F., D.R.W.). Department of Pathology, Brigham and Women’s Hospital, Boston, MA (Z.S., Y.S., C.-A.C., D.R.W.). Wyss Institute for Biologically Inspired Engineer-ing, Harvard University, Boston, MA (Z.S., Y.S., C.-A.C., D.R.W.). Ragon Institute of MGH, MIT and Harvard, Cambridge, MA (Y.C.B., E.B., B.J., G.A.). Department of Anesthesiology, Critical Care and Pain Medicine (T.N., A.G.R.), Department of Pediatrics, Division of Immunology (J.C.), and Department of Cardiology (A.D.), Boston Children’s Hospital, MA. Department of Pediatrics, Division of Infectious Diseases and Immunology, Infectious and Immunologic Diseases Research Cen-ter, and Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA (M.A.).
Sources of FundingThis research was supported by the National Institutes of Health: National Heart, Lung, and Blood Institute (5K08HL143183 to Dr Yonker), the National Insti-tute of Diabetes and Digestive and Kidney Diseases (DK104344 to Dr Fasano), National Institute of Child Health and Human Development (R01HD100022-02S2 to Dr Edlow), and National Institute of Allergy and Infectious Diseases (3R01AI072726-10S1 to Dr Arditi; 3R37AI080289-11S1, R01AI146785 and U19AI42790-01, U19AI135995-02, 1U01CA260476-01, and CIV-IC75N93019C00052 to Dr Alter). They also report funding from the Regione Campania Italy (CUP G58D20000240002-SURF 20004BP000000011 to Dr Fasano), Boston Children’s Hospital’s Taking on COVID-19 Together Study (to Dr Randolph), and MassGeneral for Children (to Dr Yonker). Funding for the SARS-CoV-2 antigen measurements came from a generous donation from Bar-bara and Amos Hostetter and the Chleck Foundation. The authors thank Nancy Zimmerman, Mark and Lisa Schwartz, an anonymous donor (financial support), Terry and Susan Ragon, and the Samana Cay Massachusetts General Hospi-tal Research Scholars award for their support. They acknowledge support from the Massachusetts Consortium on Pathogen Readiness, the Musk Foundation, and the Gates Foundation Global Health Vaccine Accelerator Platform funding (OPP1146996 and INV-001650).
DisclosuresDr Walt has a financial interest in Quanterix Corp, a company that develops an ultrasensitive digital immunoassay platform. He is an inventor of the single-molecule array technology, is a founder of the company, and serves on its board of directors. Dr Walt’s interests were reviewed and are managed by Brigham and Women’s Hospital and MassGeneral Brigham in accordance with conflict of interest policies. Dr Alter has been employed by Moderna since October 2022; her contributions to this article preceded her employment by Moderna. Dr Alter is also a founder and equity holder of Seromyx Systems, a company de-veloping a platform technology to profile antibody immunity. Drs Julg and Alter are employees and equity holders of Leyden Labs, a company developing pan-demic prevention therapeutics. Their interests were reviewed and are managed by Massachusetts General Hospital and MassGeneral Brigham in accordance with their conflict of interest policies. Dr Randolph received funding (to Boston Children’s Hospital) from the US Centers for Disease Control and Prevention to study COVID-19 complications in children outside of this work. The other authors report no conflicts.