If the shut-off were to be permanent that would work but if you wanted to turn it back on then you could have issues. If air gets into the part of the system that no longer has access to the pressurised gas supply then if air and gas mix then conditions are right to produce an explosion.

When a home is destroyed because of a "gas explosion" it is not just caused by burning gas. It happens because the ratio of air and gas was just right for an explosion to occur.