Nicotine has a psychostimulatory effect on the CNS at low doses via enhancing the actions of norepinephrine and dopamine in the brain. Anything that increase either increases voltage as can be measured by EEG. Anything that increase voltage increase the "DC electric current" in the brain.
A. Clark MA, Finkel R, Rey JA, Whalen K: Lippincott's Illustrated Reviews: Pharmacology. Baltimore/Philadelphia: Lippincott Williams & Wilkins; 2008.
B. Silvette H, Hoff EC, Larson PS, Haag HB: The actions of nicotine on central nervous system functions.Pharmacol Rev 1962, 14:137–173.
Nicotinamide, also known as niacinamide and nicotinic acid amide, is the amide of nicotinic acid (vitamin B3/ niacin). Nicotinamide is a water-soluble vitamin and is part of the vitamin B group. Nicotinic acid, also known as niacin, is converted to nicotinamide in vivo, and though the two are identical in their vitamin functions, nicotinamide does not have the same pharmacologic and toxic effects of niacin, which occur incidental to niacin’s conversion. Thus nicotinamide does not reduce cholesterol or cause flushing, although nicotinamide may be toxic to the liver at doses exceeding 3 g/day for adults. The body can synthesize niacin from the essential amino acid tryptophan, but the synthesis is extremely slow; 60 mg of tryptophan are required to make one milligram of niacin. For this reason, eating lots of tryptophan is not an adequate substitute for consuming niacin. As serotonin synthesis is reliant on tryptophan availability, inadequate dietary intake of vitamin B3 may also therefore lead to depression. Depression is a low DC current state. In cells, niacin is incorporated into nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), although the pathways for nicotinamide and nicotinic acid are very similar. NAD+ and NADP+ are coenzymes in a wide variety of enzymatic oxidation-reduction reactions.
It was discovered in 1941 that a solution of nicotine in the presence of oxygen could be converted to nicotinic acid (niacin). Both oxygen and UV light irradiation were required for this reaction to occur...
Therefore, exogenous nicotine ingestion combined with sunlight exposure and fresh air / oxygen can have heaping health benefits. Do not ingest through a smoke / inhaling device (esp if living indoors / high latitudes), since that promotes pseudo hypoxia and threatens to negate the nicotine benefits.
Nicotine has a psychostimulatory effect on the CNS at low doses via enhancing the actions of norepinephrine and dopamine in the brain. Anything that increase either increases voltage as can be measured by EEG. Anything that increase voltage increase the "DC electric current" in the brain.
A. Clark MA, Finkel R, Rey JA, Whalen K: Lippincott's Illustrated Reviews: Pharmacology. Baltimore/Philadelphia: Lippincott Williams & Wilkins; 2008.
B. Silvette H, Hoff EC, Larson PS, Haag HB: The actions of nicotine on central nervous system functions.Pharmacol Rev 1962, 14:137–173.
Nicotinamide, also known as niacinamide and nicotinic acid amide, is the amide of nicotinic acid (vitamin B3/ niacin). Nicotinamide is a water-soluble vitamin and is part of the vitamin B group. Nicotinic acid, also known as niacin, is converted to nicotinamide in vivo, and though the two are identical in their vitamin functions, nicotinamide does not have the same pharmacologic and toxic effects of niacin, which occur incidental to niacin’s conversion. Thus nicotinamide does not reduce cholesterol or cause flushing, although nicotinamide may be toxic to the liver at doses exceeding 3 g/day for adults. The body can synthesize niacin from the essential amino acid tryptophan, but the synthesis is extremely slow; 60 mg of tryptophan are required to make one milligram of niacin. For this reason, eating lots of tryptophan is not an adequate substitute for consuming niacin. As serotonin synthesis is reliant on tryptophan availability, inadequate dietary intake of vitamin B3 may also therefore lead to depression. Depression is a low DC current state. In cells, niacin is incorporated into nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), although the pathways for nicotinamide and nicotinic acid are very similar. NAD+ and NADP+ are coenzymes in a wide variety of enzymatic oxidation-reduction reactions.
It was discovered in 1941 that a solution of nicotine in the presence of oxygen could be converted to nicotinic acid (niacin). Both oxygen and UV light irradiation were required for this reaction to occur...
http://pubs.acs.org/doi/abs/10.1021/ja01846a026?journalCode=jacsat
Therefore, exogenous nicotine ingestion combined with sunlight exposure and fresh air / oxygen can have heaping health benefits. Do not ingest through a smoke / inhaling device (esp if living indoors / high latitudes), since that promotes pseudo hypoxia and threatens to negate the nicotine benefits.
Tobacco is soaked in sugar water before drying. The sugar increases the addictive nature.