So I was searching for Ivermectin articles. came across this one: https://www.nature.com/articles/ja201711

"Ivermectin’s primary target is glutamate-gated chloride channels, although it also active against other invertebrate neurotransmitter receptors, including GABA-, histamine- and pH-sensitive chloride channels.35, 36, 37 In addition, ivermectin exposure alters expression of genes involved in the reproduction mechanism of female worms, even at low concentrations"

Histamines are a big part of seasonal allergies, which I have in spades, but they're talking about histamines with relation to invertebrates.

However, in this article: https://www.uspharmacist.com/article/drug-therapy-for-common-parasitic-infections-within-the-united-states

"Enhancement of GABA activity may occur in humans as well, and ivermectin should not be coadministered with GABA-ergic drugs"

I'm wondering if Ivermectin may also tinker with histamine sensitivity. Possible there's a hidden benefit for those of us with allergies. Alternatively, it may do nothing, or may make them worse.

There appears to be some evidence, although not with respiratory symptoms - https://pubmed.ncbi.nlm.nih.gov/27566864/

"Among the 1,446 patients who had Strongyloides serologic tests ordered, 127 (8.8%) had positive test results. Eighty-four patients had follow-up data regarding allergy-type symptoms after ivermectin treatment. Among these, 52 patients (61.9%) reported skin-related problems (pruritus, urticaria, angioedema, and/or rash). Forty-nine patients (58.3%) had asthma, and 73.8% had allergic rhinoconjunctivitis. Although respiratory symptoms typically did not respond to ivermectin treatment, 24 of 48 patients (50%) with skin symptoms reported a significant subjective improvement of symptoms after ivermectin treatment."

Just some info for my frens. I have no training and this is not medical advice.