It's not even necessary for the uranium to be depleted, since that does not affect its physical and chemical properties. The use of some suitable warhead is implied by the Russian statements of having done it before. It is commonplace for such a weapon to have a terminal dive. That is what is done with our JDAM bombs, which don't even have propulsion. (The idea is to null out any lateral error resulting from elevation error magnified by a glide slope.) Whatever velocity may be lost in a turning maneuver would be repaid by gravity.

And it may not be uranium, but tungsten, with a delayed fuze explosive / thermobaric charge. Not a good idea to get caught up in particulars, when we know so little. Like not even the true depth of the penetration, or what the overburden was.