Not trolling here, I was just digging deeper on this. The rate of spontaneous abortion/miscarriage in the general population is already 10-15%. This study shows that 53 out of 458 cases ended with a miscarriage, that’s 11.6%, so this AE doesn’t seem egregious (although a very sad statistic regardless). Also, in the general population “adverse pregnancy events” occur in over half (~55%) of all pregnancies. This shows 248/458 adverse events, which is 54.1%. Again, I’m not trying to troll here, but this might not be the smoking gun that we hoped, it is maybe more of a reflection of how complicated pregnancy is in general and how sad the outcomes can be. The adverse events in this report might be more severe? Or I might be missing something else in general.
That being said, I would love to open the discussion of where I might be wrong as this was after just 20min or so of research.
Not trolling here, I was just digging deeper on this. The rate of spontaneous abortion/miscarriage in the general population is already 10-15%. This study shows that 53 out of 458 cases ended with a miscarriage, that’s 11.6%, so this AE doesn’t seem egregious (although a very sad statistic regardless). Also, in the general population “adverse pregnancy events” occur in over half (~55%) of all pregnancies. This shows 248/458 adverse events, which is 54.1%. Again, I’m not trying to troll here, but this might not be the smoking gun that we hoped, it is maybe more of a reflection of how complicated pregnancy is in general and how sad the outcomes can be. The adverse events in this report might be more severe? Or I might be missing something else in general.
That being said, I would love to open the discussion of where I might be wrong as this was after just 20min or so of research.