Scientists Find No Evidence That Depression Is Caused by “Chemical Imbalance” or Low Serotonin Levels
A comprehensive review by University College London scientists challenges the widely-held belief that depression is caused by a serotonin imbalance. The research, encompassing numerous studies and tens of thousands of participants, found no clear evidence ...
The only drug that messes with this stuff I can suggest is E, and you want to do it right (proper preloads etc). Of course, by its very nature and the fact that it's not fun in the same way for long if you repeat it too frequently, it doesn't tend to be very addictive for most.
Of course, good fucking luck getting the real thing anymore. I expect many that have done it only in the last few years if not longer, never really have.