Also, ten years earlier, Williams was in The World According To Garp. Check out this plot summary:

T.S. Garp is the out-of-wedlock son of a feminist mother, Jenny Fields, who wanted a child but not a husband. A nurse during World War II, she encounters a dying ball turret gunner known only as Technical Sergeant Garp ("Garp" being all he is able to utter) who was severely brain damaged in combat, whose morbid priapism allows her to rape him and get impregnated. She names the resultant child after Garp.“

His mother observes his interest in sex and is intellectually curious about it, having little more than clinical interest herself. She interviews a prostitute and offers to hire her for Garp. Immediately after, Jenny decides to write a book on her observations of lust and human sexuality.“

Her book is a partial autobiography, called Sexual Suspect, and is an overnight sensation. Jenny becomes a feminist icon. She uses the proceeds from the book to fund a center at her home for troubled and abused women.”

Garp spends time visiting his mother and the people who live at her center, including transgender ex-football player Roberta Muldoon.“

Garp, dressed as a woman, is infiltrated into the memorial by Muldoon.”

John Lithgow was nominated for Best Actor in a Supporting Role as Muldoon.