https://www.sciencealert.com/scientists-destroy-99-of-cancer-cells-in-the-lab-using-vibrating-molecules

https://archive.is/NObpG

Scientists Destroy 99% of Cancer Cells in The Lab Using Vibrating Molecules

Scientists have discovered a new way to destroy cancer cells. Stimulating aminocyanine molecules with near-infrared light caused them to vibrate in sync, enough to break apart the membranes of cancer cells.

Aminocyanine molecules are already used in bioimaging as synthetic dyes. Commonly used in low doses to detect cancer, they stay stable in water and are very good at attaching themselves to the outside of cells.

The research team from Rice University, Texas A&M University, and the University of Texas, says the new approach is a marked improvement over another kind of cancer-killing molecular machine previously developed, called Feringa-type motors, which could also break the structures of problematic cells.

"It is a whole new generation of molecular machines that we call molecular jackhammers," says chemist James Tour from Rice University.

"They are more than one million times faster in their mechanical motion than the former Feringa-type motors, and they can be activated with near-infrared light rather than visible light."

The use of near-infrared light is important because it enables scientists to get deeper into the body. Cancer in bones and organs could potentially be treated without needing surgery to get to the cancer growth.

In tests on cultured, lab-grown cancer cells, the molecular jackhammer method scored a 99 percent hit rate at destroying the cells. The approach was also tested on mice with melanoma tumors, and half the animals became cancer-free.

The structure and chemical properties of aminocyanine molecules mean they stay in sync with the right stimulus -- such as near-infrared light. When in motion, the electrons inside the molecules form what's known as plasmons, collectively vibrating entities that drive movement across the whole of the molecule.

"What needs to be highlighted is that we've discovered another explanation for how these molecules can work," says chemist Ciceron Ayala-Orozco from Rice University.

"This is the first time a molecular plasmon is utilized in this way to excite the whole molecule and to actually produce mechanical action used to achieve a particular goal -- in this case, tearing apart cancer cells' membrane."

The plasmons have an arm on one side, helping to connect the molecules to the cancer cell membranes while the movements of the vibrations bash them apart. It's still early days for the research, but these initial findings are very promising.

This is also the kind of straightforward, biomechanical technique that cancer cells would find it hard to evolve some sort of blockade against. Next, the researchers are looking at other types of molecules that can be used similarly

"This study is about a different way to treat cancer using mechanical forces at the molecular scale," says Ayala-Orozco.

The research has been published in Nature Chemistry.

https://www.nature.com/articles/s41557-023-01383-y

https://archive.is/a7E1n

Molecular jackhammers eradicate cancer cells by vibronic-driven action

Abstract

Through the actuation of vibronic modes in cell-membrane-associated aminocyanines, using near-infrared light, a distinct type of molecular mechanical action can be exploited to rapidly kill cells by necrosis. Vibronic-driven action (VDA) is distinct from both photodynamic therapy and photothermal therapy as its mechanical effect on the cell membrane is not abrogated by inhibitors of reactive oxygen species and it does not induce thermal killing. Subpicosecond concerted whole-molecule vibrations of VDA-induced mechanical disruption can be achieved using very low concentrations (500 nM) of aminocyanines or low doses of light (12 J cm−2, 80 mW cm−2 for 2.5 min), resulting in complete eradication of human melanoma cells in vitro. Also, 50% tumour-free efficacy in mouse models for melanoma was achieved. The molecules that destroy cell membranes through VDA have been termed molecular jackhammers because they undergo concerted whole-molecule vibrations. Given that a cell is unlikely to develop resistance to such molecular mechanical forces, molecular jackhammers present an alternative modality for inducing cancer cell death.