Its the only movie to have ever featured adrenochrome. When it was mentioned, adrenachrome was 100% unknown to the public.

It was in the book years before that. In the book, Thompson claims to have taken adrenochrome and described the effects of it. For years, people noticed that the effects he described are exactly the same as the effects of DMT. Years later, Thompson said that it was actually DMT that he took, and that he made up the idea of it being adrenochrome and the idea that adrenochrome must be harvested from a living person in order to embellish the story.