Just finished the season. Spoilers ahead so fair warning. Pedictive programming contained nukes, cannibalism, elites, and cults.
Background: Nukes are dropped. Some citizens evacuate cities to fallout shelters created by a corporation called Vault tec, to escape, live, and re-populate the earth.
Take a guess who strategizes dropping the nukes and for what reasons. All reasons we here are familiar with. Interesting the faction exposing the truth behind the lie is called New California Republic. New California also trying to recover cold fusion tech.
Edit: i never played the game so I don't know how much the series story jives with the in-game story.
New Vegas is far better than 3 anyway, it's the actual sequel to 2 and was written and developed by many of the people who worked on 1 and 2. It also has a crazy amount of branching in it's story where the side quests actually all tie into the main plot rather than in 3 where most of the side quests have nothing to do with the plot and are easily missed.