I will have to locate links. There are two from pub-med showing niacin-related deficiencies happening concurrent with plaque buildup and another showing reduction in plaques with several forms of niacin supplements. Niacin appears to mitigate/slow the damage to the brain (possibly repair with direct delivery of correct form of niacin, clinical trials needed).

Plaque buildups appear to occur due to presence of heavy metals (detox with tumeric & cilantro) and aluminum oxide (detox with zeolite binding agent, natural vitamin D cod liver oil, and apple pectin to scrape gut after Al_O pulled out of brain). Al_O in brain appears to interfere with niacin absorption/usage of braincells somehow. Dig into research and technical papers on these topics for more details. You may have to use yandex.com.