Yes. There’s even an anti parasite called Niclosamide with some nicotine like properties. Actually the original tobacco was called “little magician” for its effects on the body. You could also blow the smoke into the rectum of a drowned person and revive their heart. Crazy stories going back to the 1800s.

That term blow smoke up my ass was about the emergency use of nicotine smoke to revive people who were believed to be dead.