Gene locked weapons have been tried out so many times in science fiction, and every time -- without fail -- the realistic outcome is that those locks are bypassed, nullified or hacked in some way by unsavories, the resistance to a government, or other such groups.

Any lock can be beaten with ease, and there is automatically one fatal flaw with a lock and it is the most fatal flaw of any lock, tech based or mechanical:

Physical access. Anything can be beaten with physical access and enough time. Something you don't have with "TV locks".