I seem to recall four types of HCQ "science" paper. HCQ needs to be used with zinc. Here is my analogy. Caveat: I am not a doctor!
Remote village is constantly being raided by another tribe. The suggestion is to use guns. Those in charge do not like guns but run a test. They give the village guns and monitor the results. The village is ravaged just the same and a paper is published.
Careful readers suspect that the village was not given any ammunition. The powers that be run another test with ammunition. Another paper results and the village still suffered but did they also get guns this time someone asked.
OK, test three: Guns and ammunition issued and another test is run. Village suffers again and another paper published. Did they receive the guns and ammunition in time to stop the attack? Apparently not.
Fourth test, guns and ammunition issued in advance. Village still overrun. This time the weapons were stacked feet deep in a large container and the whole container was dropped on the village people from a great height causing severe injuries.
That is how they conducted the HCQ tests. HCQ no zinc, zinc no HCQ, HCQ and zinc too late (i.e in hospital), HCQ overdose. Result: Four papers all "proving" that HCQ did not work.
Mechanism of Action: Zinc plays a critical role in immune function and possesses direct antiviral properties by inhibiting the activity of viral RNA-dependent RNA polymerase, an enzyme essential for viral replication.
Pharmacodynamic Synergy: Hydroxychloroquine acts as a zinc ionophore, increasing the intracellular concentration of zinc by facilitating its transport into cells. Once inside the cell, zinc can inhibit viral replication processes more effectively. The combination enhances hydroxychloroquine’s antiviral properties by increasing the bioavailability of zinc at the site of viral replication, amplifying the suppression of RNA viruses.
2. Vitamin D
Mechanism of Action: Vitamin D modulates both the innate and adaptive immune systems. It enhances the production of antimicrobial peptides such as cathelicidin and defensins, which disrupt viral envelopes and inhibit viral entry into cells. It also reduces the production of pro-inflammatory cytokines like IL-6 and TNF-α.
Pharmacodynamic Synergy: Vitamin D’s ability to enhance the production of antimicrobial peptides aligns with hydroxychloroquine’s role in modulating the immune system by reducing excessive cytokine release through TLR inhibition. The combination could result in enhanced control over viral replication while simultaneously mitigating cytokine-driven inflammation, which is crucial in controlling viral pathogenesis.
3. Ivermectin
Mechanism of Action: Ivermectin has broad-spectrum antiviral activity and works by inhibiting importin α/β-mediated nuclear transport proteins, which are used by viruses like SARS-CoV-2 to access the host cell nucleus and replicate. Ivermectin disrupts viral RNA transcription and translation.
Pharmacodynamic Synergy: Hydroxychloroquine’s modulation of lysosomal pH and inhibition of endosomal viral fusion can work in tandem with ivermectin’s inhibition of nuclear transport. Together, they may target different stages of viral replication: hydroxychloroquine affecting viral entry and fusion, while ivermectin interferes with the nuclear import required for viral replication. This dual action creates a multi-step barrier to viral proliferation within the host cells.
4. Quercetin
Mechanism of Action: Quercetin is a flavonoid that acts as a zinc ionophore, facilitating the transport of zinc into cells, where it can inhibit viral replication. Quercetin also has antioxidant and anti-inflammatory properties, reducing oxidative stress and inhibiting the production of pro-inflammatory cytokines.
Pharmacodynamic Synergy: Quercetin enhances hydroxychloroquine’s ability to increase intracellular zinc levels. By acting as a zinc ionophore, quercetin synergizes with hydroxychloroquine’s own zinc-ionophore activity, potentially amplifying the intracellular concentration of zinc and inhibiting viral RNA replication. Additionally, the anti-inflammatory effects of quercetin can enhance hydroxychloroquine’s cytokine-suppressing action, providing an amplified anti-inflammatory response.
Liposomal quercetin has been reported to improve bioavailability by up to 20-fold compared to free quercetin. So if you were to take it, go for that formulation. RENUE Liposomal Quercetin Supplement https://a.co/d/el3Rl7J
if you were to take it, just make sure to stay hydrated as mixing these could cause some liver toxicity. Also keep in mind that some of these may enhance blood thinners.
I seem to recall four types of HCQ "science" paper. HCQ needs to be used with zinc. Here is my analogy. Caveat: I am not a doctor!
Remote village is constantly being raided by another tribe. The suggestion is to use guns. Those in charge do not like guns but run a test. They give the village guns and monitor the results. The village is ravaged just the same and a paper is published.
Careful readers suspect that the village was not given any ammunition. The powers that be run another test with ammunition. Another paper results and the village still suffered but did they also get guns this time someone asked.
OK, test three: Guns and ammunition issued and another test is run. Village suffers again and another paper published. Did they receive the guns and ammunition in time to stop the attack? Apparently not.
Fourth test, guns and ammunition issued in advance. Village still overrun. This time the weapons were stacked feet deep in a large container and the whole container was dropped on the village people from a great height causing severe injuries.
That is how they conducted the HCQ tests. HCQ no zinc, zinc no HCQ, HCQ and zinc too late (i.e in hospital), HCQ overdose. Result: Four papers all "proving" that HCQ did not work.
1. Zinc Supplementation
2. Vitamin D
3. Ivermectin
4. Quercetin