What 208-RZ seems to be talking is this: every time something people want is declared illegal and forced underground the end result seems to be the same. The alcohol prohibition eras of different countries are a good example, the use didn't go anywhere, people rebelled against it and that rebellion in itself became to be seen as something cool, criminal organizations for distributing the stuff were created, and patterns of use became worse.

In general, even if not using any drugs would be best, it can't be forced. The second best, and with least problems from them, seem to be societies where they are used, but the use is sort of ritualistic, those rules of use are taught to children at a fairly young age, and the socially accepted use is limited to certain places and times, if not connected to religion then to social functions, and their sale is legal but well monitored.

That - making them legally available - would make one revenue stream for the cartels less profitable. And if they had never been made illegal in the first place you maybe would not even have the kind of problem with those cartels as you now have.