A team of Chinese scientists has discovered that the spread of cancer from the original tumors to distant organs may be due to chemotherapy triggering the reactivation of dormant cancer cells...
Their findings shed light on why breast cancer patients can experience metastasis to organs such as the lungs, despite successful treatment of their primary tumors.
The team also found that using specific drugs in combination with chemotherapy could inhibit this process in mice, and a clinical trial is already underway in breast cancer patients.
"We demonstrated that chemotherapeutic drugs, such as doxorubicin and cisplatin, increase the proliferation and lung metastasis of dormant breast cancer cells," the team wrote in a paper published in the peer-reviewed journal Cancer Cell on July 3.
"This study provides direct evidence of the reactivation of latency and reveals an underlying mechanism for the detrimental effect of chemotherapy on metastasis, highlighting potential strategies to improve cancer treatment."
Researchers in the United States previously discovered that high doses of radiotherapy for treating cancer could, paradoxically, promote the growth of metastatic tumors. Many patients who undergo chemotherapy to treat primary tumors (the original site of the tumor in the body where cancer cells begin to develop) may suffer cancer relapse in other organs even after complete regression of the primary tumor.
This has led to research into whether chemotherapy may have a similar paradoxical effect, in which it treats the primary tumors while triggering cancer metastasis.
"It is postulated that the reactivation, or awakening, of dormant disseminated tumor cells (DTCs) in distant organs results in metastatic relapse after the asymptomatic period," the team stated.
Studies have shown that disseminated cancer cells, which travel from primary tumors to other parts of the body, can be present even during the early stages of primary cancer formation, according to a press release from the Chinese Academy of Sciences (CAS).
These cells can remain in a dormant state for years, during which they do not grow or multiply, allowing them to evade chemotherapy. Researchers had previously identified molecular mechanisms that regulate metastatic relapse and disseminated cancer cell latency. However, it has remained unclear whether metastasis is due to the reactivation of dormant cells or the growth of rare, non-dormant disseminated cells.
Of note, lung cancer according to German New Medicine derives from fear of death. Hence why it’s a common metastasis according to western medicine. Go into treatment after learning you may be dying, fear of dying kicks in. Food for thought.
A team of Chinese scientists has discovered that the spread of cancer from the original tumors to distant organs may be due to chemotherapy triggering the reactivation of dormant cancer cells...
Their findings shed light on why breast cancer patients can experience metastasis to organs such as the lungs, despite successful treatment of their primary tumors.
The team also found that using specific drugs in combination with chemotherapy could inhibit this process in mice, and a clinical trial is already underway in breast cancer patients.
"We demonstrated that chemotherapeutic drugs, such as doxorubicin and cisplatin, increase the proliferation and lung metastasis of dormant breast cancer cells," the team wrote in a paper published in the peer-reviewed journal Cancer Cell on July 3.
"This study provides direct evidence of the reactivation of latency and reveals an underlying mechanism for the detrimental effect of chemotherapy on metastasis, highlighting potential strategies to improve cancer treatment."
Researchers in the United States previously discovered that high doses of radiotherapy for treating cancer could, paradoxically, promote the growth of metastatic tumors. Many patients who undergo chemotherapy to treat primary tumors (the original site of the tumor in the body where cancer cells begin to develop) may suffer cancer relapse in other organs even after complete regression of the primary tumor.
This has led to research into whether chemotherapy may have a similar paradoxical effect, in which it treats the primary tumors while triggering cancer metastasis.
"It is postulated that the reactivation, or awakening, of dormant disseminated tumor cells (DTCs) in distant organs results in metastatic relapse after the asymptomatic period," the team stated.
Studies have shown that disseminated cancer cells, which travel from primary tumors to other parts of the body, can be present even during the early stages of primary cancer formation, according to a press release from the Chinese Academy of Sciences (CAS).
These cells can remain in a dormant state for years, during which they do not grow or multiply, allowing them to evade chemotherapy. Researchers had previously identified molecular mechanisms that regulate metastatic relapse and disseminated cancer cell latency. However, it has remained unclear whether metastasis is due to the reactivation of dormant cells or the growth of rare, non-dormant disseminated cells.
Of note, lung cancer according to German New Medicine derives from fear of death. Hence why it’s a common metastasis according to western medicine. Go into treatment after learning you may be dying, fear of dying kicks in. Food for thought.
https://learninggnm.com/SBS/documents/lungs.html
The Power of the Mind can help or hinder...
Thank you Joy and God bless.
Blessings to you fren!
Amen