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https://academic.oup.com/jid/article/227/11/1227/6948438?login=false

Archived Link: https://archive.ph/lPEcQ

Catbox link to not give them so much traffic https://files.catbox.moe/lokjgf.pdf

50 million people not 13 million

We conducted a cohort study with a nested case-control analysis using the GOLD and Aurum data sets from the United Kingdom Clinical Practice Research Datalink (CPRD). The CPRD is a large primary care database enrolling >50 million patients across 1900 publicly funded UK practices, and it is broadly representative of the general population for critical variables such as age, sex, and ethnicity [23].

Conclusion:

Our results do not support a role for vaccinations in the prevention of dementia. Indeed, we did not observe a decreased risk of dementia with common vaccines overall or with individual vaccines (apart from marginal effects with shingles and diphtheria vaccines). Design-specific aspects, such as the application of a nested case-control analysis that eliminated immortal time bias and the use of a 2-year lag period that minimized protopathic and early detection bias, may have accounted for the discrepancy between our results and those from previous studies.

The observed increase in the risk was unexpected. Given the lack of any biological rationale linking vaccinations to an increased risk of dementia, and considering the totality of our findings, we deem unmeasured confounding and late detection bias to be the most plausible explanations.

the recording of dementia in the CPRD has been shown to be accurate [26].

Overall, our large population-based study showed no decreased risk of dementia associated with routinely administered vaccines.

[26]

McGuinness LA, Warren-Gash C, Moorhouse LR, Thomas SL. The validity of dementia diagnoses in routinely collected electronic health records in the United Kingdom: a systematic review. Pharmacoepidemiol Drug Saf 2019; 28:244–55.

https://onlinelibrary.wiley.com/doi/10.1002/pds.4669