Info is out there. Several mechanisms, of which this is one:
"Ivermectin's primary mechanism of action involves binding selectively and with high affinity to glutamate-gated chloride ion channels found in invertebrate nerve and muscle cells, leading to increased chloride permeability, hyperpolarization, and ultimately paralysis and death of parasites.[1][2] This mechanism is highly selective for invertebrates, which explains the drug's favorable safety profile in mammals. "
Here's another :
" its antiviral mechanisms primarily involve disrupting importin-mediated nuclear transport of viral proteins and inhibiting host cell pathways that viruses exploit for replication, rather than targeting viral energy processes directly.[1][2][3]
The primary antiviral mechanism of ivermectin centers on inhibiting the importin α/β1 heterodimer complex, which viruses use to shuttle viral proteins into the nucleus for replication.[1][2][3] Ivermectin binds directly to importin-α, causing conformational changes that prevent recognition of nuclear localization sequences on viral proteins, thereby blocking their nuclear import.[2][4] This mechanism has been demonstrated against multiple RNA viruses including HIV-1, dengue, Zika, West Nile virus, and SARS-CoV-2 in vitro.[2]
Additional proposed mechanisms include blocking viral protease (3CLpro) and spike protein active sites, which disrupts viral replication and attachment machinery.[3] More recently, ivermectin has been identified as an inhibitor of inositol monophosphatase (IMPase), which reduces cellular myo-inositol and phosphatidylinositol-4-phosphate levels—lipids crucial for RNA virus replication.[5]
While ivermectin does affect cellular energy metabolism in cancer cells (inhibiting glycolysis and reducing ATP production through GLUT4/JAK/STAT pathway blockade), this represents an effect on[6] host cell metabolism rather than viral energy utilization per se. The antiviral effects appear to result from disrupting host cellular machinery that viruses co-opt, rather than directly targeting viral metabolic processes."
Info is out there. Several mechanisms, of which this is one: "Ivermectin's primary mechanism of action involves binding selectively and with high affinity to glutamate-gated chloride ion channels found in invertebrate nerve and muscle cells, leading to increased chloride permeability, hyperpolarization, and ultimately paralysis and death of parasites.[1][2] This mechanism is highly selective for invertebrates, which explains the drug's favorable safety profile in mammals. "
Here's another : " its antiviral mechanisms primarily involve disrupting importin-mediated nuclear transport of viral proteins and inhibiting host cell pathways that viruses exploit for replication, rather than targeting viral energy processes directly.[1][2][3]
The primary antiviral mechanism of ivermectin centers on inhibiting the importin α/β1 heterodimer complex, which viruses use to shuttle viral proteins into the nucleus for replication.[1][2][3] Ivermectin binds directly to importin-α, causing conformational changes that prevent recognition of nuclear localization sequences on viral proteins, thereby blocking their nuclear import.[2][4] This mechanism has been demonstrated against multiple RNA viruses including HIV-1, dengue, Zika, West Nile virus, and SARS-CoV-2 in vitro.[2]
Additional proposed mechanisms include blocking viral protease (3CLpro) and spike protein active sites, which disrupts viral replication and attachment machinery.[3] More recently, ivermectin has been identified as an inhibitor of inositol monophosphatase (IMPase), which reduces cellular myo-inositol and phosphatidylinositol-4-phosphate levels—lipids crucial for RNA virus replication.[5]
While ivermectin does affect cellular energy metabolism in cancer cells (inhibiting glycolysis and reducing ATP production through GLUT4/JAK/STAT pathway blockade), this represents an effect on[6] host cell metabolism rather than viral energy utilization per se. The antiviral effects appear to result from disrupting host cellular machinery that viruses co-opt, rather than directly targeting viral metabolic processes."