It happens when you use hopium. Hopium is a gateway drug that often leads to other dangerous stimulants. Users of hopium often develop heavy tolerances and therefore seek harder and quicker substances. This appears to be Copium. Copium is much much more dangerous and it too leads users to develop a heavy tolerance. Users that find themselves unphased by the effects of Copium are frequently forced to seek out alternatives such as Clownium to maintain their high, often ending in serious injury or death.