Trump clearly believes the vaccine is safe and effective. Perhaps the antivaccine discussion should be at conspiracies.win until Trump is shown to be wrong?
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It's a new immunological therapy. We don't know what its long term effects will be, and there could be pathogenic priming. Many cells in the body will be painted on their cell membranes with viral spike proteins made in the cells from the mRNA instructions.
When a matching virus comes along, won't the body attack its own cells which are now factories for the spike proteins now marked as a foreign virus by our immune system's reaction to the new virus?
At some place along the line, an mRNA would be created by your own body to transcribe immunoglobulins to bind to any regular vaccine. My understanding is that this mRNA is converted into an immunoglobulin that binds to the spike protein. Not the protein itself. I think they just bypassed the bodies own machinery to get to that immunoglobulin.
I think that the mRNA is to make a homologue of the viral spike protein. then the body is supposed to make the antibody for that.
Any new viral infection with a matching spike protein will illicit an immune response quickly because the antibodies are there waiting. But, the body's cells will be attacked too because they present the spike protein on their surface.
It has happened in previous trials and animal trials for SARS mRNA vaccines