Scientist here. Good summary of what i took away as the major points of the video. I would actually imagine many vaccine supporters would find common ground with Dr. Bossche on point 3. There is a real chance that as the virus remains prevalent in third world nations even after the US achieves herd immunity, COVID could very well mutate to escape vaccine immunity. This process is studied closely and is called antigenic drift. Whether those strains are more DEADLY—who knows but definitely they are a concern.
I do need to strongly disagree with point 4. mRNA has no ability to change or modify your DNA. In fact, mRNA from the vaccine cant even enter the cell's nucleus where your DNA is stored. It will only be translated into the modified covid spike proteins and then degrade over the course of hours/days. It will also have no r won't replace your natural immunity, which is a bit of a dubious concept anyways. The spike proteins will lead to amplification of B cells expressing antibodies that bind to it. Some of those B cells will turn into memory B cells which will wait in your lymph nodes for the next viral challenge, when they will quickly amplify again and fight the virus. Your body has thousands of coexisting amplified B memory cells for every virus/cold/flu you have ever faced. It doesn't replace your natural immunity —it IS your natural immunity.
There are a lot of reasonable questions and concerns about the vaccines. It IS a new technology and no one knows how effective it will ultimately be. But most all virologists (i guess not Dr. Bossche haha) agree it is safe and the best method we have to fight COVID
Im a completely healthy twenty something that is 100% certain I will survive COVID, but I am willing to "fight something" that poses no risk to me because I am concerned about my septuagenarian parents and my elderly neighbor who all seem plenty healthy, but I know don't have a 99.9% of surviving it. Hell it almost killed Trump and he wasn't on deaths door.
Is the pandemic overblown? Sure. Has our public policy been proportional to the risk? Absolutely not. But can it kill people who would otherwise have decades of life ahead of them. Definitely.
You don't have to get the vaccine—I understand anyone's concerns over a new and unproven medical technology and I hope Biden doesnt make it mandatory, but I know how they work and think it is important people know what's the actual risk and what's a baseless concern.
Hey I was excited about HCQ as a COVID treatment too! Hell there was a few weeks last March/April that I would have supported its mass production and distribution. I also think its ridiculous the FDA hasn't focused more on small molecule discovery/reuse for coronavirus. I think its stupid we haven't expanded and normalized the standard use of antibody treatments, like the ones received by Trump and Christie, too. But ultimately, there hasn't been widespread evidence HCQ actually works well, in fact it increases mortality in covid patients.
Don't forget the potential autoimmune response. Important to note, the primer sequence of the spike protein matches 93 naturally occurring sequences in the human body. Combined with the effects of pathological priming, this is potentially deadly.
What do you mean by primer sequence? The short oligonucleotide used to amplify the sequence for RT-qPCR tests? That's meaningless as far as the vaccine is concerned. These sequences are usually only ~20 nucleotides long and just by chance any ~20 nucleotide sequence is bound to show up somewhere in the genome. As for pathological priming, why would the vaccine cause autoimmunity, but the natural viral infection which causes the exact same antibody response have different outcomes?
Dr. van den Bossche has worked in virology labs all over the world. I think his explanation may bear some gravitas.
I am aware of the theory of mRNA not entering DNA, it has been repeated by the 'propaganda' (self-confessed) promulgated by the NZ government. However, messenger RNA re-programs DNA. That is its function. It does not 'enter' the DNA, but it tells it what to do. Just like software updates do not technically 'enter' your computer.
The other issue is what Dr van den Bossche points out: the antibodies are an after-party. The main immunity response are the kill cells that poison infected cells. Antibodies are a clean-up, a sort of spit and polish job. So, the presence of antibodies is just a measurement that does not really address what actually happens in immune responses. To try and stimulate their presence is like fighting a war with cotton wool and polishing rags.
The other problem he talked about is that the 'artificial' memory B cells are aimed at only the SARS/COV virus that your body has manufactured parts of, in response to instructions from the mRA. The problem occurs when your natural immunities have been displaced by the new memory B cells -the good Dr. even postulates that those amplified B cells will actually attack your natural ones - A mutation, or perhaps an attack from a completely different pathogen such as the Black Death can be devastating. There is some evidence to support the displacement of naturally occurring B-cells, in the form of triggered auto-immune disease.
I don't much care where memory B-cells are stored. Whatever. You are trying to sound scientific-like. It is a red herring. It reminds me of seventies explanations of how 'safe' vaccines were manufactured within eggs.
Scientist here. Good summary of what i took away as the major points of the video. I would actually imagine many vaccine supporters would find common ground with Dr. Bossche on point 3. There is a real chance that as the virus remains prevalent in third world nations even after the US achieves herd immunity, COVID could very well mutate to escape vaccine immunity. This process is studied closely and is called antigenic drift. Whether those strains are more DEADLY—who knows but definitely they are a concern.
I do need to strongly disagree with point 4. mRNA has no ability to change or modify your DNA. In fact, mRNA from the vaccine cant even enter the cell's nucleus where your DNA is stored. It will only be translated into the modified covid spike proteins and then degrade over the course of hours/days. It will also have no r won't replace your natural immunity, which is a bit of a dubious concept anyways. The spike proteins will lead to amplification of B cells expressing antibodies that bind to it. Some of those B cells will turn into memory B cells which will wait in your lymph nodes for the next viral challenge, when they will quickly amplify again and fight the virus. Your body has thousands of coexisting amplified B memory cells for every virus/cold/flu you have ever faced. It doesn't replace your natural immunity —it IS your natural immunity.
There are a lot of reasonable questions and concerns about the vaccines. It IS a new technology and no one knows how effective it will ultimately be. But most all virologists (i guess not Dr. Bossche haha) agree it is safe and the best method we have to fight COVID
Your motion has been seconded!!
Im a completely healthy twenty something that is 100% certain I will survive COVID, but I am willing to "fight something" that poses no risk to me because I am concerned about my septuagenarian parents and my elderly neighbor who all seem plenty healthy, but I know don't have a 99.9% of surviving it. Hell it almost killed Trump and he wasn't on deaths door.
Is the pandemic overblown? Sure. Has our public policy been proportional to the risk? Absolutely not. But can it kill people who would otherwise have decades of life ahead of them. Definitely.
You don't have to get the vaccine—I understand anyone's concerns over a new and unproven medical technology and I hope Biden doesnt make it mandatory, but I know how they work and think it is important people know what's the actual risk and what's a baseless concern.
It almost killed Trump? He was sick for three days.
Hey I was excited about HCQ as a COVID treatment too! Hell there was a few weeks last March/April that I would have supported its mass production and distribution. I also think its ridiculous the FDA hasn't focused more on small molecule discovery/reuse for coronavirus. I think its stupid we haven't expanded and normalized the standard use of antibody treatments, like the ones received by Trump and Christie, too. But ultimately, there hasn't been widespread evidence HCQ actually works well, in fact it increases mortality in covid patients.
https://www.nature.com/articles/s41598-020-77748-x
You got to use the tools you've been given and until a magic drug emerges, we are left with the only tool we have :(
Shill.
Don't forget the potential autoimmune response. Important to note, the primer sequence of the spike protein matches 93 naturally occurring sequences in the human body. Combined with the effects of pathological priming, this is potentially deadly.
What do you mean by primer sequence? The short oligonucleotide used to amplify the sequence for RT-qPCR tests? That's meaningless as far as the vaccine is concerned. These sequences are usually only ~20 nucleotides long and just by chance any ~20 nucleotide sequence is bound to show up somewhere in the genome. As for pathological priming, why would the vaccine cause autoimmunity, but the natural viral infection which causes the exact same antibody response have different outcomes?
OK. long rant.
Dr. van den Bossche has worked in virology labs all over the world. I think his explanation may bear some gravitas.
I am aware of the theory of mRNA not entering DNA, it has been repeated by the 'propaganda' (self-confessed) promulgated by the NZ government. However, messenger RNA re-programs DNA. That is its function. It does not 'enter' the DNA, but it tells it what to do. Just like software updates do not technically 'enter' your computer.
The other issue is what Dr van den Bossche points out: the antibodies are an after-party. The main immunity response are the kill cells that poison infected cells. Antibodies are a clean-up, a sort of spit and polish job. So, the presence of antibodies is just a measurement that does not really address what actually happens in immune responses. To try and stimulate their presence is like fighting a war with cotton wool and polishing rags.
The other problem he talked about is that the 'artificial' memory B cells are aimed at only the SARS/COV virus that your body has manufactured parts of, in response to instructions from the mRA. The problem occurs when your natural immunities have been displaced by the new memory B cells -the good Dr. even postulates that those amplified B cells will actually attack your natural ones - A mutation, or perhaps an attack from a completely different pathogen such as the Black Death can be devastating. There is some evidence to support the displacement of naturally occurring B-cells, in the form of triggered auto-immune disease.
I don't much care where memory B-cells are stored. Whatever. You are trying to sound scientific-like. It is a red herring. It reminds me of seventies explanations of how 'safe' vaccines were manufactured within eggs.