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34
Identification of phytocompounds from Houttuynia cordata Thunb. as potential inhibitors for SARS-CoV-2 replication proteins through GC–MS/LC–MS characterization, molecular docking and molecular dynamics simulation (www.ncbi.nlm.nih.gov)
posted 4 years ago by HughGReckshon 4 years ago by HughGReckshon +34 / -0
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▲ 6 ▼
– sjriver 6 points 4 years ago +6 / -0

I’m glad some people are smart enough to understand all that. I couldn’t make it halfway through the title without getting confused

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▲ 2 ▼
– HughGReckshon [S] 2 points 4 years ago +2 / -0

This is an older study on SARS.

https://pubmed.ncbi.nlm.nih.gov/18479853/

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▲ 3 ▼
– CQVFEFE 3 points 4 years ago +3 / -0

title is impenetrable

Disclaimer: used to be a doctor

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▲ 3 ▼
– HughGReckshon [S] 3 points 4 years ago +3 / -0

Houttuynia cordata, also known as fish mint, fish leaf, rainbow plant, chameleon plant, heart leaf, fish wort, or Chinese lizard.

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▲ 2 ▼
– Mr_A 2 points 4 years ago +2 / -0

Any clue where and how to obtain this substance? I don't recall seeing any of those names on the shelf.

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▲ 1 ▼
– HughGReckshon [S] 1 point 4 years ago +1 / -0

Did a quick search and found this place if you're in the USA.

https://www.kellynurseries.com/754-perennials/7266-houttuynia#/quantity-3

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▲ 1 ▼
– Mr_A 1 point 4 years ago +1 / -0

I was thinking tea or supplements, but this works. Thanks.

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▲ 2 ▼
– HughGReckshon [S] 2 points 4 years ago +2 / -0

I hear the best time to harvest it (for potency) is after it flowers in summer.

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▲ 1 ▼
– Southern_Belle 1 point 4 years ago +1 / -0

Try dandelion leaf.

It supposedly helps as well.

I'm steeping some now to test it out.

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▲ 1 ▼
– Mr_A 1 point 4 years ago +1 / -0

Thanks.

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▲ 3 ▼
– ARandomOgre 3 points 4 years ago +3 / -0

Wow, these guys go for all the top-shelf words. I am happy to provide a quick translation, since I read papers like this every day for a living.

These guys used gas chromatography and mass spectrometry (gc-ms) to identify some compounds in fish mint, a traditional med herb used to allegedly cure just about everything from heatstroke to cancer to infections. In general, the more unrelated conditions a drug claims to cure, the more likely it’s poppycock, but they want to test very specific chemicals in this plant against the COVID virus.

Once they identified a few compounds, they then ran computer simulations (“in silico”) to test these compounds against a few receptors in the COVID virus that allow it to replicate. They believe they found that some of these particles have a somewhat higher affinity for binding to these receptors, which would possibly make it harder for COVID to replicate in the body.

The theory, then, would that this could be useful as a mild protective agent against someone extremely early in the infection, and if a lot of Important Science was done to some of these chemicals, they may one day be helpful in creating a more powerful version of the compound to use in a treatment or vaccine.

This type of paper is VERY early-type research. Like I said, it was all done in a computer simulation. Nothing living was involved in this besides the researchers themselves. It wasn’t designed to prove anything, but to justify better experiments done by other people later (it’s hard to get funding for a research direction without going through these steps).

On the other hand, it’s fucking fish mint. If you want to take up drinking it in a tea just in case, have at it. It doesn’t look like it can hurt you, and the world can always enjoy more tea drinkers.

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▲ 1 ▼
– inquimous 1 point 4 years ago +1 / -0

You would do the world a great service by explaining "studies"! I picture a blog with the study of the day and a rating on the "Does it pass the 'So what? test'?"

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▲ 2 ▼
– livingmybestlife 2 points 4 years ago +2 / -0

say that 10 times fast!

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