It may depend on weight and age, but ivermectin has a ridiculously long half life where it takes an average of 45 days. I think 12 mg is for normal age and weight, and taking it once a month would build up that resistance. It's probably a good idea to take the first two doses within 48 hours, then once a month.
Correct, which is why you take it once a month, as there is still some left over in your system for the next dose. And there is a constant buildup of resistance.
The half life is not 45 days. The Mayo article I just read said half life was something like 8, or 18 hours, I forget. But 45 days is NOT its half life. It may be DETECTABLE 45 days later, but it would be a minuscule amount
"Due to its high lipophilic nature, ivermectin is extensively distributed with broad volumes of distribution (Vd)
in all species. It tends to accumulate in fat tissue, which acts
as a drug reservoir and the highest levels of ivermectin are
found in liver and fat, and the lowest in brain tissue.
Binding studies in dogs have shown that ivermectin binds
extensively to plasma albumin and lipoproteins (Rohrer
and Evans, 1990), and this should be considered in
undernourished animals or in diseases in which plasma
proteins decrease, as there would be a higher free fraction
of the drug. Ivermectin persists in the body for a prolonged
period, due not only to low plasma clearance but also to
this accumulation in fat tissue. "
It may depend on weight and age, but ivermectin has a ridiculously long half life where it takes an average of 45 days. I think 12 mg is for normal age and weight, and taking it once a month would build up that resistance. It's probably a good idea to take the first two doses within 48 hours, then once a month.
Half life is the time it takes for half the medicine to leave your body. It does not take 45 days for it to work.
Correct, which is why you take it once a month, as there is still some left over in your system for the next dose. And there is a constant buildup of resistance.
The half life is not 45 days. The Mayo article I just read said half life was something like 8, or 18 hours, I forget. But 45 days is NOT its half life. It may be DETECTABLE 45 days later, but it would be a minuscule amount
Hmm, i was going off the fact it's highly soluble in fat, it will stay in the system a long time.
https://parasitology.cvm.ncsu.edu/vmp930/supplement/ivermectin_pharmocology_rev2009.pdf
"Due to its high lipophilic nature, ivermectin is extensively distributed with broad volumes of distribution (Vd) in all species. It tends to accumulate in fat tissue, which acts as a drug reservoir and the highest levels of ivermectin are found in liver and fat, and the lowest in brain tissue. Binding studies in dogs have shown that ivermectin binds extensively to plasma albumin and lipoproteins (Rohrer and Evans, 1990), and this should be considered in undernourished animals or in diseases in which plasma proteins decrease, as there would be a higher free fraction of the drug. Ivermectin persists in the body for a prolonged period, due not only to low plasma clearance but also to this accumulation in fat tissue. "