Most of the protocols I've seen show it taken once a week for preventative care. Dosage normally is based on the patient's weight.
It is old enough to be free from patent protection. Don't think it would take a miracle to get new manufacturers brought online quickly or even build new facilities. I think most countries have stockpiles since it was on the WHO list of essential medications.
It may depend on weight and age, but ivermectin has a ridiculously long half life where it takes an average of 45 days. I think 12 mg is for normal age and weight, and taking it once a month would build up that resistance. It's probably a good idea to take the first two doses within 48 hours, then once a month.
Correct, which is why you take it once a month, as there is still some left over in your system for the next dose. And there is a constant buildup of resistance.
The half life is not 45 days. The Mayo article I just read said half life was something like 8, or 18 hours, I forget. But 45 days is NOT its half life. It may be DETECTABLE 45 days later, but it would be a minuscule amount
"Due to its high lipophilic nature, ivermectin is extensively distributed with broad volumes of distribution (Vd)
in all species. It tends to accumulate in fat tissue, which acts
as a drug reservoir and the highest levels of ivermectin are
found in liver and fat, and the lowest in brain tissue.
Binding studies in dogs have shown that ivermectin binds
extensively to plasma albumin and lipoproteins (Rohrer
and Evans, 1990), and this should be considered in
undernourished animals or in diseases in which plasma
proteins decrease, as there would be a higher free fraction
of the drug. Ivermectin persists in the body for a prolonged
period, due not only to low plasma clearance but also to
this accumulation in fat tissue. "
I've heard the rule of thumb is roughly enough to spread on a cracker (for the gel form), which isn't fully accurate obviously (depends on your body weight), but, gives a general sense.
It's apparently pretty cheap to manufacture, something like 50cents/pill, and you only need a few pills for a few days, then something like 1 per day for 1-2 weeks. I'm just going off of what I've heard from others who have looked into the actual use of Ivermectin more, though, the American Frontline Doctors have the treatment protocol online to confirm or correct any of this.
Conceivably, if there was a shortage, you could just convert some manufacturing plants to resolve the supply line issues ... 1-3 months at most one would think. Kind of like what they did with masks in the early days of the plandemic.
Your gel form should have markings on the tube...
If you weigh 250 (aka 1/5th of a tube meant for a 1250lb horse) then a single dose is the size of a shelled peanut. I doubt it would meaningfully spread over an entire cracker. You need to use proper dosages, not just guessing and saying its should cover a while cracker, as that is not a legit measurement. You could have a layer 1 atom thick, or smear 15 doses worth onto a cracker....
Well naturally yes, proper dosages are necessary. The point of the 'cracker measurement' was to give a visualization in the mind of roughly how much it might be. That is, it's not much.
Crackers are also not a standardized size however I am assuming most people think of a saltine by default. I would hope anyone who wants to take this actually does a little bit of research to take the correct dosage.
Most of the protocols I've seen show it taken once a week for preventative care. Dosage normally is based on the patient's weight.
It is old enough to be free from patent protection. Don't think it would take a miracle to get new manufacturers brought online quickly or even build new facilities. I think most countries have stockpiles since it was on the WHO list of essential medications.
ok cool, I guess this is similar to what I was saying in terms of dosage as .4mg per day is also 12mg per month.
Great job!
It may depend on weight and age, but ivermectin has a ridiculously long half life where it takes an average of 45 days. I think 12 mg is for normal age and weight, and taking it once a month would build up that resistance. It's probably a good idea to take the first two doses within 48 hours, then once a month.
Half life is the time it takes for half the medicine to leave your body. It does not take 45 days for it to work.
Correct, which is why you take it once a month, as there is still some left over in your system for the next dose. And there is a constant buildup of resistance.
The half life is not 45 days. The Mayo article I just read said half life was something like 8, or 18 hours, I forget. But 45 days is NOT its half life. It may be DETECTABLE 45 days later, but it would be a minuscule amount
Hmm, i was going off the fact it's highly soluble in fat, it will stay in the system a long time.
https://parasitology.cvm.ncsu.edu/vmp930/supplement/ivermectin_pharmocology_rev2009.pdf
"Due to its high lipophilic nature, ivermectin is extensively distributed with broad volumes of distribution (Vd) in all species. It tends to accumulate in fat tissue, which acts as a drug reservoir and the highest levels of ivermectin are found in liver and fat, and the lowest in brain tissue. Binding studies in dogs have shown that ivermectin binds extensively to plasma albumin and lipoproteins (Rohrer and Evans, 1990), and this should be considered in undernourished animals or in diseases in which plasma proteins decrease, as there would be a higher free fraction of the drug. Ivermectin persists in the body for a prolonged period, due not only to low plasma clearance but also to this accumulation in fat tissue. "
The dosage isn't very large.
I've heard the rule of thumb is roughly enough to spread on a cracker (for the gel form), which isn't fully accurate obviously (depends on your body weight), but, gives a general sense.
It's apparently pretty cheap to manufacture, something like 50cents/pill, and you only need a few pills for a few days, then something like 1 per day for 1-2 weeks. I'm just going off of what I've heard from others who have looked into the actual use of Ivermectin more, though, the American Frontline Doctors have the treatment protocol online to confirm or correct any of this.
Conceivably, if there was a shortage, you could just convert some manufacturing plants to resolve the supply line issues ... 1-3 months at most one would think. Kind of like what they did with masks in the early days of the plandemic.
Your gel form should have markings on the tube... If you weigh 250 (aka 1/5th of a tube meant for a 1250lb horse) then a single dose is the size of a shelled peanut. I doubt it would meaningfully spread over an entire cracker. You need to use proper dosages, not just guessing and saying its should cover a while cracker, as that is not a legit measurement. You could have a layer 1 atom thick, or smear 15 doses worth onto a cracker....
Well naturally yes, proper dosages are necessary. The point of the 'cracker measurement' was to give a visualization in the mind of roughly how much it might be. That is, it's not much.
Thanks for the visual of a shelled peanut as that is what I just took for the first time.
Crackers are also not a standardized size however I am assuming most people think of a saltine by default. I would hope anyone who wants to take this actually does a little bit of research to take the correct dosage.
We aren't talking about pills. Were talking about horse tubes. Its measured by body weight.
Read up on the iMask protocol for proper dosage.
Ivermectin is effective at all stages (80+ grannies taken off ventilators and given ivermectin have survived), but earlier the better.