This report (from back in Apr.) was not based on any evidence from an experiment, rather, he looked at the sequence and found a similarity to a sequence that causes plaques (lining up of misfolded proteins) in Alzheimer's and related diseases. There is no reason to assume that such a sequence similarity will cause the same misfolding and clumping (plaques) from the Spike protein. That doesn't mean it shouldn't be looked at, but it is not evidence that it will happen. It is certainly not evidence that it is in any way likely to happen. It takes more than any one particular region to cause a protein to misfold. Protein folding is a highly regulated mechanism, with many safeguards. Other areas of the protein than just the part that would produce the clumping contribute to potential misfoldings as well. The paper did not show any similarity to other potentially contributing regions. It did not test the protein to see if it could misfold, much less whether or not it would under in vivo conditions and form plaques.
In other words, there is absolutely nothing that can be gleaned from this report except as a place to look for further study. Extrapolating such deleterious outcomes from one particular non-experimental study is nothing but fear mongering. Again, that doesn't mean it can't happen, but this report is a loose "maybe" and nothing more.
This report (from back in Apr.) was not based on any evidence from an experiment, rather, he looked at the sequence and found a similarity to a sequence that causes plaques (lining up of misfolded proteins) in Alzheimer's and related diseases. There is no reason to assume that such a sequence similarity will cause the same misfolding and clumping (plaques) from the Spike protein. That doesn't mean it shouldn't be looked at, but it is not evidence that it will happen. It is certainly not evidence that it is in any way likely to happen. It takes more than any one particular region to cause a protein to misfold. Protein folding is a highly regulated mechanism, with many safeguards. Other areas of the protein than just the part that would produce the clumping contribute to potential misfoldings as well. The paper did not show any similarity to other potentially contributing regions. It did not test the protein to see if it could misfold, much less whether or not it would under in vivo conditions and form plaques.
In other words, there is absolutely nothing that can be gleaned from this report except as a place to look for further study. Extrapolating such deleterious outcomes from one particular non-experimental study is nothing but fear mongering. Again, that doesn't mean it can't happen, but this report is a loose "maybe" and nothing more.