Scientific hubris will most likely lead to our extinction. Some would suggest it is already happening with Covid vaccines, but I believe there are bigger and better screwups on the horizon. Humanity won't be satisfied until we've technologized ourselves right out of existence.

Artificial intelligence? Yeah! Let's give it the keys to the missile silos. Gene therapy technology for every possible ailment? What could go wrong with that? Deploying some sort of aerosol into the atmosphere to block out the sunlight? Wow, we're so smart aren't we?