"Ivermectin is a widely used antiparasitic drug and shows promising anticancer activity in various cancer types. Although multiple signaling pathways modulated by ivermectin have been identified in tumor cells, few studies have focused on the exact target of ivermectin. Herein, we report the pharmacological effects and targets of ivermectin in prostate cancer. Ivermectin caused G0/G1 cell cycle arrest, induced cell apoptosis and DNA damage, and decreased androgen receptor (AR) signaling in prostate cancer cells. Further in vivo analysis showed ivermectin could suppress 22RV1 xenograft progression. Using integrated omics profiling, including RNA-seq and thermal proteome profiling, the forkhead box protein A1 (FOXA1) and non-homologous end joining (NHEJ) repair executer Ku70/Ku80 were strongly suggested as direct targets of ivermectin in prostate cancer. The interaction of ivermectin and FOXA1 reduced the chromatin accessibility of AR signaling and the G0/G1 cell cycle regulator E2F1, leading to cell proliferation inhibition. The interaction of ivermectin and Ku70/Ku80 impaired the NHEJ repair ability. Cooperating with the downregulation of homologous recombination repair ability after AR signaling inhibition, ivermectin increased intracellular DNA double-strand breaks and finally triggered cell death. Our findings demonstrate the anticancer effect of ivermectin in prostate cancer, indicating that its use may be a new therapeutic approach for prostate cancer."
Nice one. I've saved it as PDF and added it to my "Ivermectin" file for reference. All I need now is a way of importing it into Greece without its being impounded!
How dare you share this! Ivermectin isn't good for anything. Fyi obviously sarcasm, although it's exactly the argument I got into today. Apparently the woman's research shows no evidence ivermectin is good in anyway and anyone saying otherwise is an idiot who should shut up. They proceeded to share proof with a substack? Link. Wtf is substack š
"Ivermectin is a widely used antiparasitic drug and shows promising anticancer activity in various cancer types. Although multiple signaling pathways modulated by ivermectin have been identified in tumor cells, few studies have focused on the exact target of ivermectin. Herein, we report the pharmacological effects and targets of ivermectin in prostate cancer. Ivermectin caused G0/G1 cell cycle arrest, induced cell apoptosis and DNA damage, and decreased androgen receptor (AR) signaling in prostate cancer cells. Further in vivo analysis showed ivermectin could suppress 22RV1 xenograft progression. Using integrated omics profiling, including RNA-seq and thermal proteome profiling, the forkhead box protein A1 (FOXA1) and non-homologous end joining (NHEJ) repair executer Ku70/Ku80 were strongly suggested as direct targets of ivermectin in prostate cancer. The interaction of ivermectin and FOXA1 reduced the chromatin accessibility of AR signaling and the G0/G1 cell cycle regulator E2F1, leading to cell proliferation inhibition. The interaction of ivermectin and Ku70/Ku80 impaired the NHEJ repair ability. Cooperating with the downregulation of homologous recombination repair ability after AR signaling inhibition, ivermectin increased intracellular DNA double-strand breaks and finally triggered cell death. Our findings demonstrate the anticancer effect of ivermectin in prostate cancer, indicating that its use may be a new therapeutic approach for prostate cancer."
https://pubmed.ncbi.nlm.nih.gov/36050295/
If people want source, there it is
Nice one. I've saved it as PDF and added it to my "Ivermectin" file for reference. All I need now is a way of importing it into Greece without its being impounded!
Very expensive manufactured mono-clonal antibodies is their cash model, With more side effects than horse paste it opens other revenue pathways.
How can I get my hands on this drug? Iām in Thailand.
Horse medicine...for your horse.
Alldaychemist dot com
ivermectin.com
Thanks for bringing this to us.
How dare you share this! Ivermectin isn't good for anything. Fyi obviously sarcasm, although it's exactly the argument I got into today. Apparently the woman's research shows no evidence ivermectin is good in anyway and anyone saying otherwise is an idiot who should shut up. They proceeded to share proof with a substack? Link. Wtf is substack š
Substack is a newsletter blog type site that handles infrastructure and payment as well as delivery to your subscribers.
Some of our own use it too.