...from AZ to WA. My mom just suggested that I should get the clot shot - which is not an option - to avoid any 'trouble' on the road while staying at hotels etc.
Are there any precautions that I should take, like avoiding certain areas (other than SD, LA, SF, and Portland) and should I be worried/on the lookout for anything in particular?
You should be fine. Eastern Washington is great from what I hear. Family in Seattle are as liberal as they come, jabbed to the nines, probably still masking. I'd never go there, at least not until the Great Awakening is over and all the woke nonsense is over. My niece and nephew who grew up there, used to claim Christianity but do not practice it, think Trans, et AL are all normal.
Yes, eastern WA is awesome, I have one based cousin over there. My sister in western WA is a teacher, woke, very liberal. I don't really want to go there but I have to see my 93-year-old mom, haven't seen her since 2019.