Anybody able to make a direct connection yet between the ingredients of ivermectin and the ingredients in chaga mushrooms?
🧘Mental/Physical Health 🏋🏼♂️
Reasons for suspected connection at least at key nutrient level:
- Active ingredient in both appears to be polyphenols
- Both sources appear to be micro-organisms that appear in and around mushrooms or the soil that they are in
Kitasato Institute isolated organisms from soil samples and carried out preliminary in vitro evaluation of their bioactivity.
- Heavy research was instigated into both avermectin (ivermectin precursor) AND how chaga mushroom extract works in the mid-to-late 1960s
- Ivermectin appears to be indirectly derived from quinine which was created from "the bark of trees"; Chaga mushroom grows on the "bark of trees in northern latitudes" (avermectin+HCQ=Ivermectin theory)
Some info to get you started if you want to dig into Phytonutrients:
20APR 2022; "Clinical Evidence of the Benefits of Phytonutrients in Human Healthcare": https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102588/
15DEC 2007; "New antioxidant polyphenols from the medicinal mushroom Inonotus obliquus (Chaga)": https://pubmed.ncbi.nlm.nih.gov/17980585/
10FEB 2011; "Ivermectin, ‘Wonder drug’ from Japan: the human use perspective": https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043740/
Chaga info: https://en.wikipedia.org/wiki/Inonotus_obliquus
Ivermectin appears to be derived from quinine which was created from "the bark of trees"; Chaga mushroom grows on the "bark of trees in northern latitudes"
Just like hydroxychloroquine. That's wild. Do you have a source on that?
"On the history of Cinchona bark in the treatment of Malaria": https://pubmed.ncbi.nlm.nih.gov/29737660/
My limited research has indicated that the origin of ivermectin appears to be from quinine (Cinchona bark) -> chloroquine -> hydroxychloroquine -> ivermectin (merged with something else unknown yet); Ivermectin appears to build on hydroxychloroquine but with something additional that is as of yet still mysterious.
I'm saying where did you find information about ivermectin being from quinine?
I made these historical connections:
And then I extrapolated forward based on players involved and timeframe and added this item #4 in between the 1981-87 activities of Merck and partners.
1980s Ivermectin is approved for human use (non-US) 1987; use by vets 1981; experimental ~1979
1990s FDA finally approves Ivermectin for human use (US) 12Feb-1996 after blocking it for 9 years; Actual tablets in use no than 22Nov-1996 according to this: https://www.federalregister.gov/documents/2021/07/14/2021-14935/determination-that-stromectol-ivermectin-tablets-6-milligrams-were-not-withdrawn-from-sale-for
I am filling in the gap between when the USARL stopped developing HCQ (presumably because they were working on something better), and something better appearing shortly after which appeared to be based at least in part on the HCQ research findings in terms of its impact on humans.
I am not a chemist, but one may confirm this with some chemical signature that is similar between HCQ and Ivermectin. Chemically, I suspect Ivermectin is HCQ+(Something else unknown).
I don't think avermectin, a soil dwelling bacteria is made from quinine or its analogs.
The theory is that avermectin+HCQ = Ivermectin; However, this connection is less direct or obvious than avermectin/ivermectin sharing similar phenol properties with chaga mushroom extract. It is possible that HCQ/chloroquine/quinine/Cinchona bark shares properties with chaga mushroom (which grows in birch tree bark) extract as well, thus that possible relation.
All three seem to function in a similar way. That which functions similarly may have similar ingredients?
Ivermectin was isolated from a bacterium. The chemical structure of hcq and ivermectin are nothing alike. OP doesn't do microbiology nor biochemistry..
Citation Needed
Indirectly from quinine, most directly from hydroxychloroquine which itself is 3rd generation from quinine. This is based on research periods and U.S. Army Research lab developing hydroxychloroquine in the 50s-60s (suspected from "captured" German/Nazi tech on chloroquine), and then partnering with Merck in the 70s for the development of Ivermectin with a Japanese Partner. Still unclear how much USARL was directly involved, they may have just licensed the technology.
The partnership with Merck is noted in the Ivermectin document. If you dig a little you will find the USARL partnership with Merck via some sort of partnership or licensing in the early 70s, maybe 1971-73 timeframe.
Interesting connection fren. Chaga popular with the natural types in this region. See it in tea mixtures.
Highest bioavailability of VitaminD of any known substance that is not a concentrated VitD supplement. I drink Chaga tea almost every day. If there ever was a "magic potion" for health this is it, imo.
what region? My kinda tea.