The allosteric mechanism of mTOR activation can inform bitopic inhibitor optimization
mTOR serine/threonine kinase is a cornerstone in the PI3K/AKT/mTOR pathway. Yet, the detailed mechanism of activation of its catalytic core is still unresolved, likely due to mTOR complexes’ complexity. Its dysregulation was implicated in cancer and neurod...
Yeah they’re parasitic cysts so spare me the lingo.