The top Senate Democrat, the highest-ranking Jewish elected official in the United States, spoke from the Senate floor to condemn Prime Minister Benjamin Netanyahu and call for elections to replace him.

Senator Chuck Schumer, Democrat of New York and the majority leader, on Thursday delivered a pointed speech on the Senate floor excoriating Prime Minister Benjamin Netanyahu of Israel as a major obstacle to peace in the Middle East and calling for new leadership in Israel, five months into the war.

Many Democratic lawmakers have condemned Mr. Netanyahu’s leadership and his right-wing governing coalition, and President Biden has even criticized the Israeli military’s offensive in Gaza as “over the top.” But Mr. Schumer’s speech amounted to the sharpest critique yet from a senior American elected official — effectively urging Israelis to replace Mr. Netanyahu.

“I believe in his heart, his highest priority is the security of Israel,” said Mr. Schumer, the highest-ranking Jewish elected official in the United States. “However, I also believe Prime Minister Netanyahu has lost his way by allowing his political survival to take precedence over the best interests of Israel.”