PQQ is worth using, and not only to protect against stroke damage:

Brave AI summary:

Pyrroloquinoline quinone (PQQ) demonstrates significant potential in protecting the brain from stroke damage and supporting recovery. In animal models of ischemic stroke, PQQ supplementation administered before or even after the induction of ischemia has been shown to significantly reduce the size of the damaged brain tissue region.

This neuroprotective effect is attributed to PQQ's ability to mitigate oxidative stress and excitotoxicity, which are key contributors to neuronal damage during stroke.

Studies have demonstrated that PQQ reduces ischemic damage, improves neurobehavioral scores, and decreases infarct size, even when given up to three hours after the onset of ischemia.

The protective mechanisms include scavenging reactive oxygen species (ROS) and reactive nitrogen species, which spike during stroke and brain injury, and modulating NMDA receptors to prevent excitotoxicity.

PQQ also activates protective signaling pathways, such as the phosphorylation of Akt and GSK3β kinases, which play a role in neuronal survival and metabolism.

These findings suggest that PQQ could play a valuable role in improving outcomes following a stroke, potentially enhancing quality of life by preserving brain function.

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