Prince had all sorts of pain due to his unbelievable dance moves and jumping in his high heels. He had bad hip issues but wouldn't get the surgery to fix them because of his beliefs as a Jehova's Witness and their anti-transfusion doctrine. He used a cane for a long time and was prescribed pain killers but eventually they didn't work for him anymore. He died because the pills he got on the street that were supposed to be normal pain pills were instead mostly fentanyl.

It's really sad. I don't know any other musician that was even remotely as musically talented as he was - Thousands of songs, numerous musical genres, crazy vocal range, great concerts, and the dozens of instruments he could play. He is still considered to have done the best Superbowl Halftime show (19 years ago).