The problem with this comment is that she is saying Polyethylene glycol is antifreeze; its not. That is what is used in cosmetics and toiletry products and is the main ingredient in Miralax stool softener. Its Ethylene Glycol that is antifreeze. Just because 2 chemicals sound similar, doesn't mean they are the same thing.
PEG is probably being used as a linker molecule. I'm guessing it's what links the RNA part to the lipid part. It's not like they just pour antifreeze into the vial. It's a chemical part of the biologic I bet. That being said I have in fact heard people at my company talking about how PEG linkers are the cause of toxicity when these drugs are tested in primates. At the last place I was working at they were trying to find a replacement linker because the poor mice kept having seizures.
The problem with this comment is that she is saying Polyethylene glycol is antifreeze; its not. That is what is used in cosmetics and toiletry products and is the main ingredient in Miralax stool softener. Its Ethylene Glycol that is antifreeze. Just because 2 chemicals sound similar, doesn't mean they are the same thing.
I'm copying from another forum on this topic:
PEG is probably being used as a linker molecule. I'm guessing it's what links the RNA part to the lipid part. It's not like they just pour antifreeze into the vial. It's a chemical part of the biologic I bet. That being said I have in fact heard people at my company talking about how PEG linkers are the cause of toxicity when these drugs are tested in primates. At the last place I was working at they were trying to find a replacement linker because the poor mice kept having seizures.
Yeah, the "chemical found in yoga mats" thing for Subway really impacted how this sort of thing is told.
She stated it was DERIVED from the antifreeze molecule
Doesn’t mean Ethylene glycol is good for you either. Do not give children Merilax. Magnesium works better and is something your body needs anyways.