"The Fountain" (2006) https://www.imdb.com/title/tt0414993/ also has some interesting juxtapositions showing the Spanish Inquisition leaders lust for blood was remarkably similar to the so-called "savages" of Central America doing ritual blood sacrifice and murder. No outright references to adrenochrome, but the focus on blood and genetics and their relation to knowledge, power, and time dilation cannot be missed.

It basically shows that it is the same sort of Satan-worshipping demons doing both, and alludes to the Catholic Church being controlled by demonic forces since waaaay back into the 1400s.