Please be aware that in vitro experiments demonstrate the effects of a drug or compound in a controlled environment outside of a living organism, which does not account for the complex interactions that occur in vivo. Often, findings from in vitro studies do not directly correlate with in vivo outcomes.
For example, nicotine is rapidly metabolized into its primary metabolite, cotinine, in the human body, with a half-life of approximately 2 hours. Thus, if you aim to achieve a particular clinical effect of nicotine on specific cells in the body at a desired concentration, it is crucial to consider its rapid metabolism and the subsequent downstream effects of this process.
La Quinta Columns is sensationalist; not my favorite source. I don't blame anyone for being skeptical. I don't believe the clinical data you'd want to see exists, for lack of time. But I'll share my personal anecdote, for what it's worth:
It worked for me for long covid. I got covid (whatever it actually is) very badly back in 2020, and after recovering, the symptoms would recur every few months. The recurrence of the symptoms is what I call long covid. Each time I would beat them back using nebulized hydrogen peroxide until I felt better, and yet symptoms (primary symptom being breathing difficulties) would eventually return after a few months. I tried a lot of the supplement protocols that have been shared here, because nebulizing is time-consuming and inconvenient, but since doing the nicotine patch around September last year I immediately felt much better and ditched all the supplements, and none of those symptoms have come back. So I was very happy about it, as it was by far the most effective, convenient and even the cheapest of any of the detox protocols.
Dr Bryan Ardis, the chiropractor, sounds goofy sometimes, but he has a lot of good data and links valid studies to back up his statements. Afaik no reliable studies exist on detox protocols for either covid vax or long covid detox. There are a number of reliable studies demonstrating that smokers fared better than non-smokers from covid generally; easy to find on PubMed and other sources. Not sure if there are any studies of smokers vs non-smokers regarding vaccine effects, and I'd be skeptical of most post-vax study regardless.
Dr Ardis's theory is that both covid and the vaccine are poisons delivered in a way such that in addition to the body's own tissues they become incorporated into the gut flora to continually repopulate and attack the body, and that nicotine outcompetes the spike protein's binding method, cutting off the ability to repopulate. If that's true, I suppose it's not unfair to call them self-replicating nanobots. His presentations are not hard to find by searching GAW for his name or searching nicotine as the search term. I have some of them linked in posts I've made here, if you search my own post history.
But as far as protocols go, it's easy to try, extremely low risk and even cheaper than the supplement bottles of NAC + Bromelain + whatever else. So I recommend it even if there are no studies, for anybody who suffers from long covid or wants to detox from the covid vaccine. Little to lose, lots of upside. And it worked for me.
I actually don't mind people experimenting to help themselves. At the same time I just want to make sure that people do their due diligence in researching deeply into whatever care they plan to use. I go so far that recently, even this weekend, I called the manufacturers of a liposomal EGCG suppliment because I wanted them to send me their pharmacokinetic and clinical data to prove their technology before I purchase it. In fact, one such company last week, gave me lots of material, their patent data, clinical data, and was happy to create a document. They said I was the first client to ask for such data which to me is kind of unfortunate. More people should do research and not just accept something as true even if it seems like it falls onto our side.
Really it depends on what concentrations have a clinical effect, and how long the cells need exposure.
1. Pharmacokinetics:
Nicotine Gum: Delivers nicotine quickly through the lining of the mouth, causing rapid but short-lived increases in nicotine concentration. This leads to transient spikes in cellular nicotine levels, with periods of higher concentration followed by a rapid decline.
Nicotine Patch: Provides a slow and steady release of nicotine through the skin, resulting in a stable and sustained increase in nicotine levels in the bloodstream. This steady delivery maintains a consistent cellular nicotine concentration over a prolonged period.
2. Cellular Implications:
Nicotine Gum: The intermittent spikes in nicotine levels prevent prolonged receptor activation, reducing the risk of long-term receptor desensitization and cellular adaptation, You end up with peaks of high concentrations.
Nicotine Patch: Continuous exposure to nicotine leads to sustained receptor activation, which can result in receptor desensitization or downregulation over time due to prolonged cellular exposure. You end up with steady but lower concentrations.
Please be aware that in vitro experiments demonstrate the effects of a drug or compound in a controlled environment outside of a living organism, which does not account for the complex interactions that occur in vivo. Often, findings from in vitro studies do not directly correlate with in vivo outcomes.
For example, nicotine is rapidly metabolized into its primary metabolite, cotinine, in the human body, with a half-life of approximately 2 hours. Thus, if you aim to achieve a particular clinical effect of nicotine on specific cells in the body at a desired concentration, it is crucial to consider its rapid metabolism and the subsequent downstream effects of this process.
Even so, it works in vivo.
Can I see the clinical data?
La Quinta Columns is sensationalist; not my favorite source. I don't blame anyone for being skeptical. I don't believe the clinical data you'd want to see exists, for lack of time. But I'll share my personal anecdote, for what it's worth:
It worked for me for long covid. I got covid (whatever it actually is) very badly back in 2020, and after recovering, the symptoms would recur every few months. The recurrence of the symptoms is what I call long covid. Each time I would beat them back using nebulized hydrogen peroxide until I felt better, and yet symptoms (primary symptom being breathing difficulties) would eventually return after a few months. I tried a lot of the supplement protocols that have been shared here, because nebulizing is time-consuming and inconvenient, but since doing the nicotine patch around September last year I immediately felt much better and ditched all the supplements, and none of those symptoms have come back. So I was very happy about it, as it was by far the most effective, convenient and even the cheapest of any of the detox protocols.
Dr Bryan Ardis, the chiropractor, sounds goofy sometimes, but he has a lot of good data and links valid studies to back up his statements. Afaik no reliable studies exist on detox protocols for either covid vax or long covid detox. There are a number of reliable studies demonstrating that smokers fared better than non-smokers from covid generally; easy to find on PubMed and other sources. Not sure if there are any studies of smokers vs non-smokers regarding vaccine effects, and I'd be skeptical of most post-vax study regardless.
Dr Ardis's theory is that both covid and the vaccine are poisons delivered in a way such that in addition to the body's own tissues they become incorporated into the gut flora to continually repopulate and attack the body, and that nicotine outcompetes the spike protein's binding method, cutting off the ability to repopulate. If that's true, I suppose it's not unfair to call them self-replicating nanobots. His presentations are not hard to find by searching GAW for his name or searching nicotine as the search term. I have some of them linked in posts I've made here, if you search my own post history.
But as far as protocols go, it's easy to try, extremely low risk and even cheaper than the supplement bottles of NAC + Bromelain + whatever else. So I recommend it even if there are no studies, for anybody who suffers from long covid or wants to detox from the covid vaccine. Little to lose, lots of upside. And it worked for me.
I actually don't mind people experimenting to help themselves. At the same time I just want to make sure that people do their due diligence in researching deeply into whatever care they plan to use. I go so far that recently, even this weekend, I called the manufacturers of a liposomal EGCG suppliment because I wanted them to send me their pharmacokinetic and clinical data to prove their technology before I purchase it. In fact, one such company last week, gave me lots of material, their patent data, clinical data, and was happy to create a document. They said I was the first client to ask for such data which to me is kind of unfortunate. More people should do research and not just accept something as true even if it seems like it falls onto our side.
I wonder if the gum is any better/worse
Get the nicoret brand,not the generic,it tasts like wax.
Really it depends on what concentrations have a clinical effect, and how long the cells need exposure.
1. Pharmacokinetics:
Nicotine Gum: Delivers nicotine quickly through the lining of the mouth, causing rapid but short-lived increases in nicotine concentration. This leads to transient spikes in cellular nicotine levels, with periods of higher concentration followed by a rapid decline.
Nicotine Patch: Provides a slow and steady release of nicotine through the skin, resulting in a stable and sustained increase in nicotine levels in the bloodstream. This steady delivery maintains a consistent cellular nicotine concentration over a prolonged period.
2. Cellular Implications:
Nicotine Gum: The intermittent spikes in nicotine levels prevent prolonged receptor activation, reducing the risk of long-term receptor desensitization and cellular adaptation, You end up with peaks of high concentrations.
Nicotine Patch: Continuous exposure to nicotine leads to sustained receptor activation, which can result in receptor desensitization or downregulation over time due to prolonged cellular exposure. You end up with steady but lower concentrations.