Has fluid in his lungs. Fever over 100. Oxygen was in the 60s at home & got up to 90s with oxygen in the ER. They think the appendix is infected too.
As much as we disagree, he is the one who taught me to question everything & look on both (all) sides of every issue to figure out what both sides were refusing to discuss.
He will likely be healed up here soon, really my mother & family could use strength to care for him as he recovers. He hit his head a few weeks ago & hasn't quite been the same... Though still as stubborn as ever 😆
When it is time for him to go, it is his time. The family could really just use some support & blessings. Likely everyone in this board could use more during these times too.
That is amazing! I would love to see a website like that, or maybe even have a printed book if you ever put one together.
I have a publisher friend that was telling me nonfiction books are the ones the like printing because they stand the test of time. Fiction are just throw away books from his data, except for children's picture books.
It was a fascinating lunch discussion with them. They were saying anyone who wants to publish fiction should do short stories published by Amazon to build a following & then once you have enough (thousands of followers/fans, preferably ovrr 250k+) then it would be an appropriate time to try your hand at the multi book sagas like Wheel of Time, Way of Kings, Lord of the Rings, etc... The data shows that you lose about 10% of the readers every sequel on average (1M>900k>810k>729k>656.1K...) unless you start with tens or hundreds of millions of readers, anything more than a trilogy ends up being really hard to sell (rare rare exception like Harry Potter).
They still have reference books their father published before they were born that get requested for purchase occasionally, & when a group finds it fascinating they can quickly reprint the book again because they have the files ready to print & send out again. Every few years this seems to happen, so those non fiction books are the ones they really like to publish. I was amazed at how many ways he has to do contracts & it is all up to how much equity the writer wants to maintain, how marketing the writer wants the publisher to do, how much funding the writer wants to put down vs needing the publisher to pony up for the books to be printed, etc... I was never aware of how many ways contracts could be created for that industry. It was quite insightful.
Either way, the information you have found sounds like a fantastic resource.
I would love to know which products are the most bioavailable that you have found. I know from my own experience that some work better than others & haven't even scratched the surface of which ones are the best for all the products I am trying to learn about. I do know that the cyanide B12 doesn't work well for myself or children, but it did for my cousins. I forget the formulation of B12 we ended up with, but I know to avoid the cyanide based one.
Well I am talking about pharmacokinetic formulations which drive bioavailability and not chemical formulations but in terms of chemical formulations, here is some on B12.
1. Methylcobalamin
2. Hydroxocobalamin
As far as pharmacokinetics goes I will give an example using curcumin.
Absolute Bioavailability of Curcumin
Enhancing Bioavailability with Liposomal and Nano Formulations
Liposomal Formulations: Liposomes encapsulate curcumin in phospholipid bilayers, enhancing its absorption by improving solubility and protecting it from degradation. Liposomal curcumin can increase bioavailability by up to 8-10 times compared to standard curcumin.
Nano Formulations: Nanoparticle-based delivery systems, such as nanomicelles or nanocurcumin, can enhance curcumin’s solubility, stability, and permeability. Nano-curcumin has been shown to increase its bioavailability around 40-fold in clinical studies, allowing for more effective therapeutic outcomes.
These advanced formulations bypass some of the limitations of curcumin’s natural form, offering more consistent therapeutic effects at lower doses.
The best form I have found is Nanocur. https://a.co/d/4NzSVqK I reached out to the company and recieved their pharmacokinetic and pharmcodynamic data, patents, etc. It's is a nano formulation wrapped in a beta-cyclodextrin complex. It's nearly 100% bioavailable. The size is 5nm which is amazingly small, a blood cell is roughly 6,000 yo 8,000 nm. Is almost small enough to passively pass through cells which is 1nm. So it still needs endocytosis to enter the cell, but it does so very well.
I had never be aware of pharmacokinetics information.
That is a fascinating study there. I clearly need to learn more about the size of cells & how delivery systems may effect products inside out body.
Thank you for this!
How did you learn about, or first discover pharmacokinetics?
I would reccomend just a lot of study. I got into it due to my dad getting stage 4 lung cancer. So I dived deep into research.