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posted ago by Narg ago by Narg +115 / -0

https://makisw.substack.com/p/research-ivermectin-in-alzheimers

Link to Research article: https://www.tandfonline.com/doi/full/10.1080/17582024.2025.2554374

Conclusions

Ivermectin demonstrates protective effects in the STZ-induced Alzheimer’s model by reducing pathological changes and Aβ plaques, acetylcholinesterase activity, as well as improving memory and learning.

Plain Language Summary

Alzheimer’s disease is a neurological disease and the most common cause of dementia in the elderly. Despite progress in Alzheimer’s research, there is no definitive cure for this disease, and therefore, more research is needed to find new drugs to treat this disease. Our previous study showed the neuroprotective effects of ivermectin in ischemic stroke. Hence, our aim in the present study was to investigate the possible beneficial and therapeutic effects of ivermectin in Alzheimer’s disease. For this purpose, we first induced Alzheimer’s in rats and then treated them with ivermectin at a dose of 2 mg/kg for three days. The results we obtained showed that administration of ivermectin can reduce brain tissue damage and improve memory and learning. Ivermectin also caused a decrease in the activity of the acetylcholinesterase enzyme. This enzyme breaks down acetylcholine, a neurotransmitter that plays a crucial role in memory and learning. Therefore, a decrease in the activity of this enzyme reduces the loss of acetylcholine. This study concludes that ivermectin could be considered as a potential treatment for Alzheimer’s disease. It should be noted that this study was conducted on laboratory animals and further studies are needed to confirm its use in humans.