Cannabis has the same down regulated effects as opioids, or SSRIs. My patients who use for pain, a certain percentage, just like in opioids, after about a week they need to triple the initial amount taken.

Biology lesson: you have ten receptors before exogenous cannabis use, after you input exogenous versus your natural endogenous cannabinoids you lose 6 receptors as your body tries to equalize what’s normal.

So if you are an unlucky down regulator, and notice you need more and more to achieve the same benefits, I recommend taking weed breaks to offset the process and restore your receptors. No need to panic or quit.

If you do lose receptors the problem is you are now enjoying less benefit from cannabinoids than someone who has a healthy endogenous supply of endocannabinoids.

So at the end of a streak of heavy use, you have suboptimal results and your body has actually less of the substance you are trying to benefit from.

Two words: weed breaks