1. Zinc Supplementation
- Mechanism of Action: Zinc plays a critical role in immune function and possesses direct antiviral properties by inhibiting the activity of viral RNA-dependent RNA polymerase, an enzyme essential for viral replication.
- Pharmacodynamic Synergy: Hydroxychloroquine acts as a zinc ionophore, increasing the intracellular concentration of zinc by facilitating its transport into cells. Once inside the cell, zinc can inhibit viral replication processes more effectively. The combination enhances hydroxychloroquine’s antiviral properties by increasing the bioavailability of zinc at the site of viral replication, amplifying the suppression of RNA viruses.
2. Vitamin D
- Mechanism of Action: Vitamin D modulates both the innate and adaptive immune systems. It enhances the production of antimicrobial peptides such as cathelicidin and defensins, which disrupt viral envelopes and inhibit viral entry into cells. It also reduces the production of pro-inflammatory cytokines like IL-6 and TNF-α.
- Pharmacodynamic Synergy: Vitamin D’s ability to enhance the production of antimicrobial peptides aligns with hydroxychloroquine’s role in modulating the immune system by reducing excessive cytokine release through TLR inhibition. The combination could result in enhanced control over viral replication while simultaneously mitigating cytokine-driven inflammation, which is crucial in controlling viral pathogenesis.
3. Ivermectin
- Mechanism of Action: Ivermectin has broad-spectrum antiviral activity and works by inhibiting importin α/β-mediated nuclear transport proteins, which are used by viruses like SARS-CoV-2 to access the host cell nucleus and replicate. Ivermectin disrupts viral RNA transcription and translation.
- Pharmacodynamic Synergy: Hydroxychloroquine’s modulation of lysosomal pH and inhibition of endosomal viral fusion can work in tandem with ivermectin’s inhibition of nuclear transport. Together, they may target different stages of viral replication: hydroxychloroquine affecting viral entry and fusion, while ivermectin interferes with the nuclear import required for viral replication. This dual action creates a multi-step barrier to viral proliferation within the host cells.
4. Quercetin
- Mechanism of Action: Quercetin is a flavonoid that acts as a zinc ionophore, facilitating the transport of zinc into cells, where it can inhibit viral replication. Quercetin also has antioxidant and anti-inflammatory properties, reducing oxidative stress and inhibiting the production of pro-inflammatory cytokines.
- Pharmacodynamic Synergy: Quercetin enhances hydroxychloroquine’s ability to increase intracellular zinc levels. By acting as a zinc ionophore, quercetin synergizes with hydroxychloroquine’s own zinc-ionophore activity, potentially amplifying the intracellular concentration of zinc and inhibiting viral RNA replication. Additionally, the anti-inflammatory effects of quercetin can enhance hydroxychloroquine’s cytokine-suppressing action, providing an amplified anti-inflammatory response.
- Liposomal quercetin has been reported to improve bioavailability by up to 20-fold compared to free quercetin. So if you were to take it, go for that formulation. RENUE Liposomal Quercetin Supplement https://a.co/d/el3Rl7J
- if you were to take it, just make sure to stay hydrated as mixing these could cause some liver toxicity. Also keep in mind that some of these may enhance blood thinners.
Well I am talking about pharmacokinetic formulations which drive bioavailability and not chemical formulations but in terms of chemical formulations, here is some on B12.
1. Methylcobalamin
- Oral Bioavailability: Around 50–70% in individuals with normal gastrointestinal function. Methylcobalamin is better absorbed and retained in tissues compared to other forms, particularly for neurological benefits.
2. Hydroxocobalamin
- Oral Bioavailability: Approximately 40–70%, depending on the dose. Hydroxocobalamin is well-absorbed but tends to be more efficiently retained in the body compared to methylcobalamin, making it a good option for long-term storage and gradual release of B12.
As far as pharmacokinetics goes I will give an example using curcumin.
Absolute Bioavailability of Curcumin
- Oral Bioavailability: Extremely low (<1%) when consumed in its natural form. Curcumin undergoes extensive metabolism in the liver and intestinal walls, leading to poor plasma and tissue concentrations. Studies indicate that standard curcumin has very limited systemic availability after oral administration. Mainly due to its hydrophobic nature.
Enhancing Bioavailability with Liposomal and Nano Formulations
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Liposomal Formulations: Liposomes encapsulate curcumin in phospholipid bilayers, enhancing its absorption by improving solubility and protecting it from degradation. Liposomal curcumin can increase bioavailability by up to 8-10 times compared to standard curcumin.
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Nano Formulations: Nanoparticle-based delivery systems, such as nanomicelles or nanocurcumin, can enhance curcumin’s solubility, stability, and permeability. Nano-curcumin has been shown to increase its bioavailability around 40-fold in clinical studies, allowing for more effective therapeutic outcomes.
These advanced formulations bypass some of the limitations of curcumin’s natural form, offering more consistent therapeutic effects at lower doses.
The best form I have found is Nanocur. https://a.co/d/4NzSVqK I reached out to the company and recieved their pharmacokinetic and pharmcodynamic data, patents, etc. It's is a nano formulation wrapped in a beta-cyclodextrin complex. It's nearly 100% bioavailable. The size is 5nm which is amazingly small, a blood cell is roughly 6,000 yo 8,000 nm. Is almost small enough to passively pass through cells which is 1nm. So it still needs endocytosis to enter the cell, but it does so very well.
First thing to note is that phytochemicals have low bioavailability, using nano or liposomal formulations greatly enhance their clinical effects.
1. Phytochemicals with Combined Properties
A. Silymarin
- Source: Milk thistle (Silybum marianum)
- Diuretic Action: Enhances bile flow and supports kidneys in eliminating excess fluid, thereby reducing water retention.
- Antibiotic Activity: Exhibits antibacterial properties, particularly against Staphylococcus aureus and Escherichia coli.
- Hepatoprotective Properties: Stabilizes cellular membranes, reduces oxidative stress, and promotes liver regeneration. Used in treating cirrhosis, hepatitis, and fatty liver disease.
B. Berberine
- Source: Goldenseal (Hydrastis canadensis), Barberry (Berberis vulgaris)
- Diuretic Action: Enhances urine production and reduces water retention.
- Antibiotic Activity: Exhibits broad-spectrum antibacterial effects against Streptococcus pneumoniae, Staphylococcus aureus, Helicobacter pylori, and others.
- Hepatoprotective Properties: Reduces liver inflammation, oxidative stress, and lipid accumulation, showing benefits in non-alcoholic fatty liver disease (NAFLD) and hepatitis.
C. Curcumin
- Source: Turmeric (Curcuma longa)
- Diuretic Action: Promotes diuresis through kidney support and inflammation reduction.
- Antibiotic Activity: Effective against Escherichia coli, Staphylococcus aureus, and Candida albicans (antibacterial and antifungal properties).
- Hepatoprotective Properties: Reduces oxidative damage, inflammation, and fibrosis in liver cells, beneficial in NAFLD, alcoholic liver disease, and cirrhosis.
D. Green Tea Polyphenols (EGCG)
- Source: Green Tea (Camellia sinensis)
- Diuretic Action: Enhances kidney function and fluid excretion to reduce water retention.
- Antibiotic Activity: Effective against Helicobacter pylori and Staphylococcus aureus.
- Hepatoprotective Properties: Reduces fat accumulation, oxidative stress, and inflammation, useful in preventing liver disorders like NAFLD.
E. Gingerol
- Source: Ginger (Zingiber officinale)
- Diuretic Action: Promotes kidney function and reduces water retention, especially in the context of inflammation.
- Antibiotic Activity: Exhibits antimicrobial properties, particularly against Escherichia coli, Salmonella spp., and Candida albicans.
- Hepatoprotective Properties: Reduces inflammation, lipid peroxidation, and fibrosis in the liver, useful in toxin-induced liver injury and fatty liver disease.
2. Non-Phytochemical Supplements with Similar Properties
A. Taurine
- Diuretic Action: Acts as a mild diuretic, supporting fluid balance by enhancing kidney function.
- Antibiotic Activity: Though not directly an antibiotic, taurine supports immune function, helping to protect against bacterial infections.
- Hepatoprotective Properties: Reduces liver inflammation, fibrosis, and oxidative damage. Particularly useful in alcohol-induced liver damage and NAFLD.
B. N-Acetylcysteine (NAC)
- Diuretic Action: Indirect diuretic action by reducing oxidative stress and supporting kidney function.
- Antibiotic Activity: NAC disrupts biofilms, making it useful in conjunction with antibiotics for chronic bacterial infections.
- Hepatoprotective Properties: Boosts glutathione levels in the liver, reducing oxidative stress and improving liver detoxification. Used in acetaminophen toxicity and liver fibrosis.
C. Alpha-Lipoic Acid (ALA)
- Diuretic Action: Enhances kidney function and has mild diuretic effects.
- Antibiotic Activity: Possesses antimicrobial activity against some bacterial strains, particularly in reducing inflammation associated with infections.
- Hepatoprotective Properties: ALA is a potent antioxidant, protecting the liver from oxidative damage and promoting detoxification, especially in conditions like hepatitis and cirrhosis.
D. Vitamin E
- Diuretic Action: Supports fluid balance through its antioxidant effects, indirectly aiding kidney function.
- Antibiotic Activity: Though not an antibiotic, its immune-boosting properties help reduce infection risk.
- Hepatoprotective Properties: Vitamin E reduces oxidative damage in liver cells and has been studied in NAFLD and other liver conditions to reduce fibrosis and inflammation.
There are plenty of people here that are Jews that do not follow Talmud, nor are they from the same tribe. Also, if he were part of the tribe, he could still be innocent himself. I don't think he is personally, but indictments against an individual for the actions of a tribe is wrong.
Im running a script to convert any lowercase into small caps.
THE NEW YORK A.G. USED A STATUTE TO GO AFTER ME THAT HAS NEVER BEEN USED BEFORE, NOT ONCE, FOR SUCH A PURPOSE. IT, IN AND OF ITSELF, IS SOOO UNCONSTITUTIONAL AND UNFAIR. UNDER THIS STATUTE, I GET NO JURY AND HAVE NO RIGHTS. Aʟʟ DECISIONS AND RIGHTS ARE GIVEN TO, IN THIS CASE, A CORRUPT, TRUMP HATING JUDGE, WHO CAME UP WITH A CRAZY, OUT OF THIN AIR AWARD, IN ORDER TO DAMAGE ME POLITICALLY, AND NOT ALLOW ME TO USE ANY OF THE LARGE AMOUNT OF CASH I HAVE BUILT UP OVER THE YEARS, THROUGH HARD WORK, INSIGHT, INSTINCT, AND DILIGENCE, ON MY POLITICAL CAMPAIGN FOR PRESIDENT. THAT IS JUST WHAT CROOKED JOE BIDEN WANTED THIS POLITICAL HACK, COUPLED WITH A CORRUPT AND RACIST ATTORNEY GENERAL, TO DO. I DID NOTHING WRONG! THIS IS SIMPLY A “TAKING.” MUCH LIKE WHAT IS DONE IN COMMUNIST COUNTRIES, AND WILL LEAVE AN IRREPARABLE STAIN ON NEW YORK STATE AND ITS JUDICIAL SYSTEM. IT IS TOTALLY UNCONSTITUTIONAL, INCLUDING THE HARSH GAG ORDER IMPOSED. THE STATUTE OF LIMITATIONS WAS ALREADY RULED ON, FOR ME!
Have you acknowledged anything I've asked? Or have you instead given a red herring, evasion, ad hominem?
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I opened the page you sent about Jesus being a myth. Unfortunately for that idea, not a single employed biblical scholor would agree. Even the athiest Bart Ehrman conceded that Jesus existed.
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Sataniss are the enemy yes. Regardless of if satan exists. But If satan himself exists, satan is the enemy as well. All I know is that if I was satan and I wanted to take the souls of as many as I could, I would make false religions, and false theologies like Jesus being a myth so people feel good about living without knowing Jesus and without being saved.
Not sure why but you seem to be projecting an attitude on to me. Honestly, you just seem confused or something. I was just clarifying that you do fall into one of those categories. Materialism is the hardest one to defend, platonism or deism is likely the easiest.
- a materialist (nothing but the physical universe)
- a platonist (logical/conceptual universe alongside the material universe)
- a universal naturalist. (Non God, non intelligent, creator which is spaceless and timeless.)
- a diest. (God exists but is impersonal)
- a theist (God exists and is personal) There is nothing left. If you say you aren't any of them, you are just confused.
Pretending everyone is wearing one is certainly on the same level as flat earth.