I'll preface this with a reminder of HOW TERRIFIED the dirtbags who want you to DIE from lack of this information are, and what they are DOING to Dr. Makis (and others, of course) for daring to tell you how you might safely save the lives of your family members or yourself.
Alberta Government has FROZEN my Stripe Account, @X or Twitter income, SUBSTACK income, and GiveSendGo $199,370 Legal fundraiser! They are stealing all my sources of income!
https://makismd.substack.com/p/breaking-news-alberta-government
If you can do anything to get that story to Elon via X or to anyone one else who might have some pull, directly or otherwise, please consider doing so.
Now back to the headlined post:
Almost the entire post here is a set of images of an article in The Journal of Orthomolecular Medicine, from 2024. Dr. Makis' post about this was published in October of that year.
Targeting the Mitochondrial-Stem Cell Connection in Cancer Treatment: A Hybrid Orthomolecular Protocol
Non-Substack members may not be able to view the images of the article's pages, so I've included a direct link to the ISOM site (International Society of Orthomolecular Medicine, which publishes the aforementioned Journal) at the bottom of this post.
https://makismd.substack.com/p/breaking-news-first-in-the-world
My Take…
This paper [the link BELOW Dr. Makis' comments here] is the FIRST peer-reviewed and Published paper in the world to propose a Cancer Treatment Protocol based on the incredible properties of IVERMECTIN, MEBENDAZOLE and FENBENDAZOLE.
This was truly a labor of love.
My thanks to lead authors Ilyes Baghli and Pierrick Martinez for their incredible inspired work, FLCCC’s Dr.Paul Marik for his extensive work on repurposed drugs and every co-author who worked hard to bring this paper to life.
I hope that this paper lays the groundwork for a brand new future for Cancer Treatment.
Most awesome. Thanks for this. I had privilege of putting this good man in contact with a friend who is very knowledgeable on DMSO. Hope they will come up with something good.
Yes, DMSO is another important medicine that Establishment forces have demonized and worked to keep hidden. I suspect Makis will indeed make use of your information; he's that kind of guy.
Ordered some 4 ounce containers with squeeze droppers. Pour in some 80% DMSO from Amazon Measured a 250lb dose of Ivermectin and shake
You will get a milky white mixture of Ivermectin in a solution of DMSO, which will carry the ivermectin straight into your skin, or if your pet has lice, fleas, mites, etc. Just a few drops and rub into their skin. Emphasis on a FEW DROPS.
Warts, skin lesions, spots you may feel may turn into cancerous, just don't look right. Don't put a lot on, as the DMSO in concentrated form may burn a bit. A little bit goes a long way.
DMSO on an extremity like lets say a hand will travel through entire body in less than 60 sec. Will be detectable on feet in less than 60 sec is what I am saying. Impressive substance.
It will bring what ever is infused into it with it as we also call it a Carrier.
Jeez sounds like the “real” delivery system vs the toxic mRNA! Interesting!
hell, you just sparked a thought I will have to explore. What if instead of injections one could utilize the properties of DMSO. Will snoop around some clever minds.
Thanks for this.
Let us know what you find!!
Suggestion: Because DMSO will absorb other substances through the skin along with the DMSO itself, use high purity DMSO (99.9%).
80% pure means 20% impure. These impurities will also absorb into your system.
also be sure skin is impeccably clean before applying DMSO
Yes bodybuilders who are afraid of needles use it to get testosterone into their bodies they mix the testosterone with it and rub it on. Testosterone must be injected it cannot be taken orally DMSO is an alternative.
Hmm...interesting. I was always afraid to get even a little bit of it on my skin. I bet some people are so comfortable with it that they almost bath in it, lol.
Yea dump it on it burns and makes you itch for about 10 minutes, I used to rub it on my swollen knees and the next day the swelling was down more than half. The burning and itching is your pores opening up and the DMSO is entering through your skin.
If you use anything close to 100% pure DMSO, you should (for most uses) first dilute it with distilled water. I buy 70% DMSO for this reason; the other 30% isn't "impurities" it's distilled water. (Not saying there isn't contaminated DMSO out there, but I've never run into such. Check labels, etc).
A sample of info available on the web:
https://search.brave.com/search?q=DMSO+USES+AND+ADVICE
Thanks for the link, I'll look into it.
Not correct. The body is 80% water roughly and this proportion has to be matched for max absorption into body via the skin. When taken orally a max proportion is fine just make sure to drink a large glass of water as DMSO will Dehydrate. It is in fact a solvent used for degreasing tools.
Always dilute Dry DMSO with distilled water to a 80%
99% is called Wet. 1% is tree juice/water. 99.9% is called Dry 0.1% tree juice/water 99.99 is also Dry but superior quality 0.01% tree juice/water
All 3 will do same job and only difference is taste when taken orally
BTW you do know DMSO is considered an ORGANIC substance in Any purity, Yes ?.
An 80:20 solution of 99.9+% DMSO to very pure water I can see may be no problem as far as purity goes, if that is what is used to dilute the DMSO. The concern is any impurities in the substance used to dilute the 99.9+% DMSO to get a 80:20% solution. For that matter, any residual impurities left in the manufacturing process of DMSO would be absorbed, too. 99:1% is pretty pure DMSO, but what is the 1% composed of? Personally, I would wonder about that if I were to use DMSO (then probably just get over it and use it anyway if I really wanted to try it).
What is tree juice?
Yes, DMSO (dimethyl sulfoxide) is an organic compound because it contains 2 methyl groups, CH3. Each methyl group has one carbon atom, making it organic.
I am using 90%. It burns if you put it on your skin directly. Cotton swab and rub is fine. But a drop sitting is like a chemical burn.
It’s potent. So dilute with rubbing alcohol or water. It gets the job done.
He was expressing a need for options to penetrate the brain barrier. DMSO is already used with FenBen we know. Question is, will it work with IVM. I am sure it will but I am not a scientist :)
DMSO is the most researched substance in US medical data base. I thing last I looked 36k hits
DMSO makes me a bit nervous, as Undine53 had posted about using it shortly before she died. Not that it’s necessarily causative or anything, but seeing her post about it just a few months before definitely made me pause.
As was recently pointed out to Patrick Gunnels by Lee Merritt, it matters what’s on your skin when you use it, so be careful!
Not necessarily discouraging anyone from using it, just that for non-medical people, careful approaches seem best, as you can’t unscramble an egg.
“Read the User Manual” for sure.
Be careful with DMSO, I use non alcohol sterile swabs to apply it.
Not me I dump it on and rub it in, don't spill it on anything it will ruin it. I buy it in roll on form like deoderant's
I remember back in the '80s? (or was it '70s) when DMSO was widely discussed and used. From my memory, it was used for arthritis?
I was going to post exactly what you just posted. I remember that it was a "thing" in the 80s. And, yes, it was popularly being used for joint pain.
Yes, and for many other things. It's surprisingly versatile.
Correct. And still works for that as well :)
But that smell. DMSOstinks horribly ,gets in clothes and bedding. Has anyone used a dmso brand that does not stink?
The S in DMSO is sulfur, as in rotten eggs.
It is a solvent. Do not apply to any artificial matter.
I have used DMSO it is very good anti inflammatory, It burns terribly and it makes you itch but it goes away in about 10 minutes and it will leave a funny taste in your mouth it is a by product of making paper. You can buy it in most places the sell horse products. We also used to inject in cows lungs for abscess that impinge on their breathing you inject and the breath right away.
Summary
A New Approach to Cancer Treatment: Targeting Mitochondria and Stem Cells
Cancer is one of the most challenging diseases to treat, with conventional therapies like chemotherapy and radiation often having serious side effects and limited success in preventing recurrence. A new approach, called the Mitochondrial-Stem Cell Connection (MSCC) Theory, suggests that cancer may arise due to dysfunction in mitochondria—the tiny power plants inside cells that generate energy. This theory proposes that when mitochondria fail to function properly in stem cells, those cells may turn into cancer stem cells (CSCs), which can drive tumor growth and spread.
Based on this idea, a hybrid orthomolecular protocol has been developed to restore mitochondrial function, cut off the fuel supply to cancer cells, and target cancer stem cells directly. This protocol combines:
Nutritional supplements (vitamins and minerals)
Repurposed drugs (medications originally meant for other diseases, like ivermectin and mebendazole)
Dietary changes (fasting and ketogenic diet)
Additional therapies (exercise and hyperbaric oxygen therapy)
Understanding the Mitochondrial-Stem Cell Connection (MSCC) Theory
Traditional cancer treatments focus on attacking rapidly dividing cells, which often leads to short-term tumor shrinkage but does not necessarily eliminate cancer stem cells (CSCs). CSCs are a small but highly dangerous group of cancer cells that can survive treatment, causing cancer to return or spread to other parts of the body.
The MSCC theory suggests that cancer arises because mitochondria in stem cells fail to produce enough energy through oxidative phosphorylation (OxPhos)—a process cells use to generate energy. When mitochondria are impaired, cancer cells rely more on sugar (glucose) and the amino acid glutamine to survive and grow. The MSCC approach targets these energy sources while also attempting to restore proper mitochondrial function.
Key Strategies in the Hybrid Orthomolecular Protocol
To attack cancer from multiple angles, the hybrid orthomolecular protocol includes:
Restoring mitochondrial function so that normal cells can function properly while cancer cells are weakened.
Cutting off cancer’s fuel supply by blocking glucose and glutamine metabolism.
Directly killing cancer stem cells to prevent recurrence and metastasis.
This protocol is not meant to replace conventional treatments but to be used alongside or as an alternative in some cases.
Step 1: Nutritional and Vitamin Therapies
Vitamin C (Intravenous Therapy)
High-dose intravenous vitamin C has been shown to kill cancer cells while leaving healthy cells unharmed.
Vitamin C works by generating hydrogen peroxide, which selectively destroys cancer cells.
It also improves mitochondrial function and enhances the effects of chemotherapy.
Vitamin D
Vitamin D plays a role in immune function and cancer prevention.
Cancer patients often have low vitamin D levels, and supplementation may improve survival rates.
High doses of 50,000 IU/day may be necessary to reach optimal blood levels.
Zinc
Zinc helps protect mitochondria from damage and boosts the immune system.
Some studies suggest it may reduce cancer stem cells’ ability to grow and spread.
It also makes cancer cells more sensitive to chemotherapy.
Step 2: Repurposed Drugs with Anti-Cancer Properties
Several existing drugs have shown promising anti-cancer effects by targeting metabolism and stem cells.
Ivermectin (commonly used for parasites)
Induces cancer cell death by disrupting mitochondrial function.
Targets cancer stem cells more effectively than chemotherapy in some studies.
Inhibits glucose metabolism, starving cancer cells.
Benzimidazoles (Mebendazole & Fenbendazole) (used for parasites)
Blocks glucose uptake in cancer cells, preventing them from getting energy.
Induces apoptosis (cell death) in cancer cells.
Shows effectiveness against brain tumors and drug-resistant cancers.
DON (6-diazo-5-oxo-L-norleucine)
A powerful glutamine-blocking drug that starves cancer cells of their second primary fuel.
Specifically targets cancer stem cells and metastases.
Works even better when combined with the ketogenic diet.
Step 3: Dietary Interventions to Cut Off Cancer’s Fuel Supply
Fasting
Fasting triggers autophagy, a process where the body breaks down damaged cells, including cancer cells.
It lowers glucose and glutamine levels, making it harder for cancer to survive.
Fasting increases the effectiveness of chemotherapy and reduces side effects.
Ketogenic Diet
A low-carb, high-fat diet that forces the body to burn fat for energy instead of glucose.
Cancer cells cannot effectively use ketones for energy, making them weaker.
Reduces inflammation and tumor growth.
A ketone metabolic therapy (KMT) version of the diet provides additional ketones to further deprive cancer cells of fuel.
Step 4: Additional Therapies for Mitochondrial Health
Exercise
Regular moderate-intensity exercise boosts mitochondrial function and helps the body remove damaged cells.
Improves glucose metabolism, reducing the fuel available to cancer cells.
Hyperbaric Oxygen Therapy (HBOT)
Cancer thrives in low-oxygen environments.
HBOT increases oxygen levels in the body, making it harder for cancer cells to survive.
Works well when combined with a ketogenic diet.
How to Follow the Protocol
The protocol suggests a 12-week treatment plan, though adjustments may be needed based on individual response.
Basic Protocol for All Cancer Types
Vitamin C (IV) – 1.5g/kg, 2-3x per week.
Vitamin D – 50,000 IU/day for deficiencies, then reduce to 2,000 IU/day for maintenance.
Zinc – 1 mg/kg/day, then maintain with 5 mg/day.
Ivermectin – Dosage varies based on cancer severity (0.5–2 mg/kg).
Mebendazole – 200–1500 mg/day, or DON (for aggressive cancers).
Ketogenic Diet – 900–1500 kcal/day with a glucose-ketone index (GKI) below 2.0.
Fasting – 3–7 days every 3–4 weeks for aggressive cases.
Exercise – Moderate activity, 3x per week.
Hyperbaric Oxygen Therapy – 1.5–2.5 ATA, 2-3x per week.
What This Means for Cancer Patients
This multi-targeted approach focuses on starving cancer cells, restoring mitochondrial function, and killing cancer stem cells—something that traditional treatments fail to do.
It is not a “cure,” but it offers a promising adjunct therapy that may improve survival and reduce side effects.
More research and clinical trials are needed to validate its effectiveness.
Consult with a healthcare provider before starting any new treatment.
Key Takeaways
Cancer may originate from dysfunctional mitochondria in stem cells.
Cutting off glucose and glutamine starves cancer cells.
Repurposed drugs like ivermectin and mebendazole show promise in targeting cancer stem cells.
Dietary interventions like fasting and keto can enhance cancer treatment.
Exercise and oxygen therapy support mitochondrial function.
This protocol offers a new perspective on cancer treatment, focusing on metabolism and stem cells rather than just attacking rapidly dividing cells. With further research, it may become an essential tool in the fight against cancer.
This alone could be a great post
Wow this is why we need experts because fighting any illness effectively will be multi-pronged and you need to know the right dosage and when and for how long to take these medicines and vitamins. I’d prefer to not have to figure it out by myself. Excellent! Thanks
This. It took me forever to find dosage guidance on ivermectin when it started showing up, and there’s a lot of info in research papers that isn’t very accessible to laypersons.
Maybe if we ran papers through AI rewrites to make them into more basic English?
Now that’s a good use of AI!
Very nice. Thanks.
“… prescribing fasting as an anticancer drug may not be far away if large randomised clinical trials consolidate its safety and efficacy” (Deligiorgi, et al., 2020).
Will need info on this, like time frames.
OK got the answer in above post
"Fasting – 3–7 days every 3–4 weeks for aggressive cases."
Thanks PL
Wow!
This is one reason I’ve been reluctant about even ivermectin, awesome as it seems. They can still corrupt it, they can still control us with it, and more than that…
Luke 17:21 Neither shall they say, Lo here! or, lo there! for, behold, the kingdom of God is within you.
So there should be nothing we need from without.
Further, “antibiotics” can eventually result in “antibiotic resistant bacteria”. If it’s possible that antiparasitics can result in antiparasitic resistant parasites, the verses about “where their worm dieth not” take on a whole new meaning as well.
Do not get too excited about this until adequate research has been done. Store it in the "of interest, possibly worth trying if needed, but not safe for prevention" pigeon hole. Cancer is not a single disease but this could point to a common point of treatment.
Sunlight exposure seems to be better than vitamin D and may have multiple benefits that are additive.
That dose of vitamin C can be expected to cause oxalate kidney stones and kidney damage. It will cause oxidative damage to tissues. Perhaps lower doses may work?
Exercise must include endurance exercise = long slow distances of fairly high intensity with heart rate about 75% of maximum attainable. Strength exercise in a gym with increasing resistive exercises may help too. This will need lots of training and if there are already health problems it is best to do it with the help of a personal trainer or exercise Physiotherapist. Ensure adequate water and electrolytes (water alone will cause low serum sodium that can be lethal).
Short term fasting may help too = late breakfast and early supper with at least 16 hours of no food, but adequate water. Very low carbohydrate and plenty of mammalian fat to give enough energy for exercise.
I agree. It is a theoretical paper, but they do seem to have compiled a lot of non-mainstream ideas together, which is a good sign. Needs testing, though.
Says who?
If cancer is a disruption of the mitochondria, then it is a single disease. It's just that different people manifest it in different ways.
Both heart attack and stroke can be caused by the same problem, but some people get one and others get the other, due to the specifics of what is going on inside them.
Cancer might be the same. If so, any general prevention should be effective against all cancers, but some protocols might do better against certain cancers.
It is rare for a patient to have more than one sort of cancer at a time, uncommon to have more than one sort over a life time. People who have multiple cancers seem to run in families. Genetic aberrations known to be associated with cancers are associated with a single type of cancer across many patients. Any given type of cancer has similar natural histories in many patients. When a patient has different cancers they each tend to behave in a way that is typical of the cancer, not of the patient. Known causes of cancers tend to cause single types of cancer.
Possibly whatever causes cancer can affect the mitochondria in a way that affects energy (ATP) production. If this is true then it would be a convenient way to treat all (or many) cancers.as suggested in the original post. There are many causes of both heart attack and stroke, some common to both and others affecting only one organ.
Dr. Pauling explained that vite C washes our of the body and is not stored. It dkes not "accumulate" as stones. But obviously, drink lots of water, with a pinch of sea salt per quart. Which you should be doing anyway.
Bookmarked and saved for reposting to my website (with credit to sauce of course). Knowledge is power, which is powerful for the forward-thinking among us.
Look up the book Healing with DMSO.
Spoke to author years ago and we compared notes. Same conclusions via different routes.
Very good book,and cheap :)
Thanks u/Narg ! Especially for the fasting parts!
Just watched another doctor in South America go down for this right before making this meme https://greatawakening.win/p/19AdX9yW5g/how-to-cure-cancer--step-1/c/ just seven days ago.
We have to get this info out!!! Distribute the f out of it! Backup! Backup! Backup!
https://web.archive.org/web/20250128210721/https://isom.ca/article/targeting-the-mitochondrial-stem-cell-connection-in-cancer-treatment-a-hybrid-orthomolecular-protocol/
Awesome - 🙏
It is great that people are looking at this. However, I strongly suspect that healthy food and plenty of exercise would eliminate most illnesses.
I agree, HOWEVER ...
What exactly is "healthy food" is the big question.
Certainly, ANYTHING that the WHO and similar corrupt organizations and governments (and the medical industry itself) are pushing is likely to be the opposite of healthy.
Grow it or buy from local farmers.
Correct however when food/water/air is getting used as carrier of nefarious substances there is only so much our immune system can do. A helping hand is ok :)
Good point. I believe that we need state-level control to stop pollution, not federal, since it is not in the Constitution, and the EPA is totally corrupt.
Looks like they are on the right track, but it is important to note that this paper is based on theory, and they did not actually cure anyone of cancer.
Still, they hit all the notes in the alternative medicine space, by stating that fasting, ketogenic diets, and exercise all help in stopping cancer.
The added supplements might make it even better, but they have not proven that in this paper. They are just stating recommendations based on what they read elsewhere.
Will be interesting to see if someone can put together a clinical trial to test this.
The big money Big Medicine/Big Pharma industry will be against this, but I hope they can prove their theory.
Probably the main reason that they've tried to put Dr. Makis in prison and have now blocked every source of his income is that he is publishing correspondence from people who HAVE USED Ivermectin, Fenbendazole, and/or Menbendazole (and typically other things as well) to halt the progression of aggressive cancers or outright cure themselves, sometimes when they were at death's door when they started. There's a lot more than theory that supports the use of these drugs.
The plural of anecdote is not data. Well planned and prolonged research is needed. Since this will be extremely expensive with no hope of profit being generated I see no chance that this will be done unless governments pay for it.
Anecdotes ARE a type of data, and in many of the sciences collections of anecdotes are the ONLY kind of data. To ignore anecdotal, real-world evidence is to ignore reality. Not saying there's no place for controlled studies -- of course there is, in situations that allow them. But studies and lab research are NOT the whole of reality and often miss important things that can't, or can't yet, be studied in a lab.
Until anything is honestly measured and described it is as useful as a cool breeze. If lives are at risk and it is to be taken seriously there needs to be independent verification by other researchers.
The COVID disaster shows what happens when governments believe "experts" without the numbers. Social Sciences are full of feeling and opinion, but seldom have any sign of reality. Fine Art needs its special forms of measurement to succeed it its various. environments.
I have used DMSO it is very good anti inflammatory, It burns terribly and it makes you itch but it goes away in about 10 minutes and it will leave a funny taste in your mouth it is a by product of making paper. You can buy it in most places the sell horse products. We also used to inject in cows lungs for abscess that impinge on their breathing you inject and the breath right away.
Big Yes here. Been used by live stock owners for decades.
I definitely recommend Dr Marik’s 2nd edition book, published in late 2024. He covers this protocol in detail, but also has much info about other repurposed drugs and natural solutions to fight cancer. He has spent much time researching all the technical papers that show promise, results. https://www.amazon.com/dp/0960126503?ref=ppx_yo2ov_dt_b_fed_asin_title I’m spending much time doing further research into a paper he references re mushroom alternatives that are specific to particular cancers.
https://www.sciencedirect.com/science/article/pii/S0753332221008908
Thank you, P0ndHawk! Good information. I'll get the book and check out the link.
Nice. I have a buddy who for years been looking at properties of mushrooms and how infusing with DMSO will enhance effects. Will forward to him.
I’m so excited because I was concerned that I’d have to figure this all out on my own should I ever get sick.
Thank you for posting this!
F
How about a Fisher-price'd version so the simple folks understand????