TL:DR -- If you're not taking melatonin now, start. If you have cancer, you'd be suicidal to NOT add melatonin to what you're doing. Lots of data supports this.
I decided to post this partly because of the comment below, which I've never seen in reference to any other medicine or supplement:
Melatonin is probably the safest medical compound available, with a LD50 of infinity (it is impossible to kill an animal with industrial doses of melatonin). The only side effects reported are early morning drowsiness and “bad dreams” (when the dose is increased too rapidly). (1)
https://paulmarik.substack.com/p/cancer-hates-darkness-the-remarkable
. . . Anti-angiogenesis is one of the major mechanisms by which melatonin exerts its anticancer effects. Melatonin inhibits hypoxia-induced factor 1-α thereby preventing vascular endothelial growth factor (VEGF) expression. Melatonin also inhibits endothelial cell migration, endothelial cell invasion, and endothelial cell tube formation. It also prevents cancer cell migration via alteration of PI3K and MAPK signaling pathways in both receptor-dependent and independent manner. (11) Melatonin has been demonstrated to stimulate T cell and natural killer (NK) production and reduce regulatory T cells (Tregs). (18, 19)
Melatonin may benefit cancer patients who are also receiving chemotherapy, radiotherapy, supportive therapy, or palliative therapy by improving survival and ameliorating the side effects of chemotherapy.
Clinical studies
In addition to case studies, (20, 21) the clinical benefit of melatonin in patients with cancer is supported by the highest level of evidence, namely meta-analyses of RCTs. (22, 23) A classic systematic review of randomized trials (10 RCTs, mostly solid tumors) found that adding melatonin (typically 20 mg nightly) to chemotherapy or supportive care reduced 1‑year mortality (relative risk roughly halved) and improved tumor remission rates, with consistent effects across cancer types and doses.(22) Seely et al systematically reviewed the effects of melatonin in conjunction with chemotherapy, radiotherapy, supportive care, and palliative care on 1-year survival, complete response, partial response, stable disease, and chemotherapy-associated toxicities. (23) This analysis included 21 randomized studies, all of which studied solid tumors. The pooled relative risk (RR) for 1-year mortality was 0.63 (95% CI = 0.53-0.74; P < 0.001). Improved effects were found for complete response, partial response, and stable disease. In trials combining melatonin with chemotherapy, adjuvant melatonin decreased 1-year mortality (RR = 0.60; 95% CI = 0.54-0.67).
A triple‑blind RCT in breast cancer patients undergoing adjuvant radiotherapy (20 mg daily) showed significant reductions in fatigue, anxiety, and depression scores in the melatonin group versus placebo, suggesting a clinically meaningful improvement in radiotherapy‑related symptom burden. (24) A 2024 review of 46 clinical trials of melatonin in oncology (11 with published results) reported that the most consistent positive signals were in improved quality of life and reduced treatment‑related fatigue and sleep disruption, particularly when used adjunctively with chemotherapy or radiotherapy.(25)
Types of cancers that melatonin may be beneficial for
Melatonin may be active in several cancers including cancers of the breast, ovary, pancreas, liver, kidney, mouth, stomach, colon/rectum, brain, lung, prostate, head and neck, and various leukemias and sarcomas. (2, 9)
Dosing and cautions
Despite the expanding literature, there is currently no universally accepted “optimal” anticancer dose of melatonin. Most clinical studies have used doses substantially higher than those commonly prescribed for insomnia. The pioneering work of Paolo Lissoni and colleagues employed melatonin at a dose of 20 mg nightly in patients with advanced malignancies and reported improvements in treatment tolerance, quality of life, and, in some studies, survival outcomes when combined with standard cancer therapies. (26-28) Consequently, 20 mg at bedtime remains the best-studied dose in oncology. However, many integrative oncology practitioners now use doses ranging from 20 to 40 mg nightly, based on the hypothesis that higher concentrations may be required to achieve some of the metabolic and signaling effects observed in laboratory studies.(29, 30) While some clinicians have explored doses exceeding 50–100 mg daily, robust clinical evidence demonstrating superior anticancer efficacy at these higher doses remains lacking. [On the other hand, remember the LD:50 of "infinity"; use as much as you think might be helpful. I personally take about 500mg]
Although melatonin has an excellent safety profile, initiating therapy at the target dose may lead to transient side effects such as morning drowsiness, vivid dreams, dizziness, or headache. For this reason, a gradual titration strategy is generally recommended. Many clinicians begin with 5–10 mg at bedtime and increase the dose every one to two weeks as tolerated until a target range of 20–40 mg nightly is reached. This approach improves tolerability while allowing patients to identify the lowest effective dose that balances potential therapeutic benefit with minimal adverse effects. Most side effects diminish after several days of continued use.
. . . While it has been claimed and widely disseminated in social media that melatonin is associated with cardiac failure (abstract presented at AHA Scientific Session 2025) this study is profoundly flawed and indeed, melatonin is cardioprotective. (31-36)
(lots of graphics and references in the original)
Before you use the conventional medical system or Big Pharma for ANYTHING, you'd be a fool not to DO YOUR OWN RESEARCH FIRST.
Just my opinion.
Text information with more information (than you see below) in the original.
Yes, there's a paywall.
https://makisw.substack.com/p/news-new-cancer-injection-eliminated
. . . The jab, called amivantamab, was given to people who had stopped responding to standard treatments.
Research shows the injection of amivantamab shrank tumours in 43 of the 102 patients, including 15 whose tumours disappeared completely.
Experts say the results of this clinical trial are promising.
Amivantamab is a targeted cancer treatment designed to block several of the signals that help cancer cells grow and spread. It is made by Johnson & Johnson and is already used to treat certain types of lung cancer.
ANALYSIS:
Always look at the financial benefits first. Then work backwards.
Amivantamab, a targeted therapy made by Johnson & Johnson is already used for lung cancer.
Amivantamab costs between $250,000 and $330,000 per year. (!!)
Is it curative? Of course not! (Don't be silly)
If you believe the Big Pharma Clinical Trials (like the MARIPOSA trial), this $300k drug will give you a few months extra before your cancer comes back and will give you a few months extra overall survival.
Then there are the side effects, of course.
Grade 3 Side Effects are “Serious” Side effects (the Grading scale goes up to 4).
35-80% of patients had Grade 3 or higher side effects (!!)
Could Ivermectin, Mebendazole, Fenbendazole or combinations thereof be far superior to this $300k drug? Absolutely.
But imagine $3000/year worth of Ivermectin & Mebendazole vs $300,000 worth of Amivantamab.
Some people make the argument that if Ivermectin worked better for cancer, all Oncologists would use it.
Yes, humans, especially in highly competitive corporate environments, routinely take 99% salary and profit cuts for the sake of the greater good.
(Hint: they don’t).
That’s why we need Ivermectin Clinical Trials in Florida
(more)
I had a skin cancer (mole) removed from my face several months ago. I had another mole appear on my wrist that had VERY similar characteristics to the one on my face. Rather than doing another round of "get a dermatologist to have it biopsied, and then have it completely removed if cancer is found", I started treating it with ivermectin (horese paste). I put a dab of it on the mole and covered with a bandaide twice a day. I did that for about six weeks. It maintained the red appearance throughout, and I didn't think it was working as hoped, so I stopped the ivermectin and switched to tea tree oil for a few days, again with no apparent change in the appearance. I went back to the ivermectin for another week or so, and then just quit any treatment. Within another week or so, the mole shrank and disappeared by the end of about two weeks. The ivermectin horse paste is only 1.87% ivermectin, so I wonder how effective a higher strength ivermectin paste would be, if it was the reason the mole was knocked out. And now I don't know if the tea tree oil had any effect or not, but I think there are probably many combinations of things out there that could have amazing results, but of course, the establishment medical community would not like those combinations validated, or even talked about. I would be interested in hearing if others here at GAW have used ivermectin horse paste to treat any skin conditions.
This video is a year old but it's worth reading the comments below the video, even if you don't watch it.
Also good for Red Pilling friends.
The Cancer Doctor
