profoundly impaired CD4+ and CD8+T cell activation and increased PD-1 and LAG-3 expressions in these T cells.
For those curious what this means:
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- Impaired T Cell Activation: CD4+ T cells, also known as helper T cells, are crucial for initiating and coordinating the immune response. CD8+ T cells, or cytotoxic T cells, are responsible for directly killing infected or cancerous cells. If the activation of these cells is impaired, the immune system's ability to recognize and respond to pathogens, cancer cells, or other threats is weakened. This can result in a diminished ability to clear infections or control tumor growth.
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- Increased PD-1 Expression: PD-1 (Programmed Cell Death Protein 1) is an inhibitory receptor found on the surface of T cells. When PD-1 binds to its ligands (PD-L1 or PD-L2), it sends a signal that reduces T cell activity, leading to "exhaustion" of T cells. This is a mechanism often exploited by cancer cells to evade the immune system. Increased PD-1 expression on T cells would therefore further inhibit their function, leading to reduced immune surveillance and a weakened response against tumors or chronic infections.
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- Increased LAG-3 Expression: LAG-3 (Lymphocyte-activation gene 3) is another inhibitory receptor that functions similarly to PD-1. It negatively regulates T cell activation and proliferation. Increased expression of LAG-3 would compound the effects of PD-1, further dampening T cell responses.
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Overall Impact: The combination of impaired T cell activation and increased inhibitory signals (via PD-1 and LAG-3) would lead to a state of immune exhaustion. This would result in a reduced ability to fight infections, a higher likelihood of chronic infections persisting, and an increased risk of cancer cells evading immune detection and growing unchecked.
- Aspartic Acid+Phenylalanine+Methanol→Aspartame+Water. After roughly 86 degrees aspartame breaks down back into Aspartic Acid, Phenylalanine, and Methanol.
Aspartic Acid:
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Neurotoxicity: Aspartic acid functions as an excitatory neurotransmitter, meaning it helps transmit nerve impulses. This is a normal and essential function in the brain. High doses of aspartic acid have been shown to cause neurotoxic effects in some animal studies.
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Inflammation: Some studies have investigated the relationship between amino acids like aspartic acid and inflammation. Elevated levels of excitatory amino acids could theoretically influence inflammatory processes
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Cancer: Certain studies have suggested that aspartic acid might influence oncogenic pathways
Phenylalanine
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Neurotoxicity: high levels of phenylalanine can accumulate in the brain, leading to neurotoxicity. Symptoms include intellectual disability, behavioral problems, and seizures.
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Inflammation: Elevated phenylalanine levels, may influence inflammatory processes. For example, it might affect the production of inflammatory mediators or impact gut health.
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Cancer: There is some evidence suggesting that alterations in amino acid metabolism, including phenylalanine, could be linked to cancer development. Phenylalanine's role in cellular processes and its impact on neurotransmitter levels may influence cancer progression.
Methanol
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Neurotoxicity: Methanol itself is not highly toxic, but it is metabolized in the liver to formaldehyde and formic acid, both of which are highly toxic. Formaldehyde can damage neural tissues, and formic acid can interfere with cellular respiration and lead to metabolic acidosis, which can affect the nervous system.
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Inflammation: The metabolism of methanol to formaldehyde and formic acid generates reactive oxygen species (ROS), which can cause oxidative stress. Oxidative stress is known to induce inflammatory responses and damage tissues.
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Cancer: Methanol itself is not classified as a human carcinogen. However, its metabolite, formaldehyde, is a known carcinogen. Formaldehyde has been associated with various cancers, including nasopharyngeal cancer and leukemia.
No prob, here is more extensive post i just made https://greatawakening.win/p/17txk2VCxG/monkeypox-treatment-from-my-own-/
HOW TO TREAT YOURSELF FROM MONKEYPOX (From my own research)
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- Inhibition of Viral Entry and Attachment
Flavonoids
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Most Flavonoids and other phytochemicals, have a very low absorption rate between 0 and 5% Purchasing nano or liposomal versions along with peperine enhances absorption to nearly 100%
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Quercetin
- Mechanism: Quercetin interferes with the virus's ability to bind to and enter host cells. It can stabilize cell membranes and block viral adhesion.
- Dosage: 500-1,000 mg/day, divided into 2-3 doses. Higher doses may be used in acute situations under professional supervision.
- Toxicity: Generally well-tolerated. High doses may cause gastrointestinal upset, headache, or fatigue. Long-term high doses could impact kidney function.
- Cautions: Can interact with certain medications, including blood thinners (e.g., warfarin) and some antibiotics, potentially affecting their efficacy.
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Catechins (e.g., Epigallocatechin Gallate - EGCG)
- Mechanism: EGCG prevents the attachment of viruses to host cells and inhibits viral entry. It also has anti-inflammatory and antioxidant properties.
- Dosage: 200-400 mg/day. Higher doses may be considered for acute symptoms with medical guidance.
- Toxicity: Typically safe in moderate doses. High doses may affect liver function or cause gastrointestinal disturbances. May interact with anticoagulant medications.
- Cautions: EGCG can interact with anticoagulants and antiplatelet drugs, increasing bleeding risk. It may also affect the absorption of some medications.
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- Disruption of Viral Replication
Saponins
- Ginsenosides (from Panax Ginseng)
- Mechanism: Ginsenosides can inhibit viral replication by disrupting viral enzyme activities and modulating the host cell’s antiviral responses. They also enhance the immune response.
- Dosage: 200-400 mg/day. Acute dosing should be managed by a healthcare professional.
- Toxicity: Generally safe. High doses may cause insomnia, nervousness, gastrointestinal issues, or affect blood sugar levels.
- Cautions: Ginsenosides may interact with anticoagulants, diabetes medications, and immunosuppressants. Use cautiously with other supplements that affect blood sugar or immune function.
Tannins
- Ellagic Acid
- Mechanism: Ellagic acid inhibits viral replication by blocking viral RNA/protein synthesis. It also has antioxidant properties that protect host cells from damage.
- Dosage: 100-300 mg/day. Acute treatment may involve higher doses under medical supervision.
- Toxicity: Usually well-tolerated. High doses might cause gastrointestinal issues or allergic reactions. Limited data on long-term high-dose safety.
- Cautions: Can inhibit the absorption of certain minerals (e.g., iron). Caution is advised if taken with iron supplements or medications affecting mineral absorption.
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- Modulation of Immune Response
Terpenes
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Limonene
- Mechanism: Limonene enhances immune function and has direct antiviral properties. It may help modulate inflammatory responses and support overall immune health.
- Dosage: 250-500 mg/day. Acute treatment should involve careful dosing.
- Toxicity: Generally safe at recommended doses. High doses may cause gastrointestinal issues or skin irritation.
- Cautions: Limonene may interact with medications metabolized by the liver’s cytochrome P450 enzymes. Caution is advised if taking drugs processed by these enzymes.
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Thymol
- Mechanism: Thymol boosts immune function and exhibits direct antiviral activity, potentially reducing viral load and inflammation.
- Dosage: Typically used in topical applications at concentrations of 0.5%-2%. Oral or high doses should be managed carefully.
- Toxicity: Essential oil can be irritating. High doses may lead to nausea, vomiting, or liver toxicity. Use cautiously in children or during pregnancy.
- Cautions: Avoid excessive use, particularly with other irritants or in sensitive individuals.
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- Protease Inhibition
Glycyrrhizin (from Licorice Root)
- Mechanism: Glycyrrhizin inhibits viral proteases, crucial for viral maturation and replication. It can reduce viral load and enhance the host’s antiviral response.
- Dosage: 100-400 mg/day. Acute situations might require higher doses under supervision.
- Toxicity: Long-term or high doses can cause hypertension, hypokalemia, and fluid retention. Not recommended for individuals with cardiovascular issues, high blood pressure, or renal problems.
- Cautions: Glycyrrhizin may interact with antihypertensive medications, diuretics, and corticosteroids. Caution is needed for those with cardiovascular issues or on medications affecting blood pressure.
Quercetin
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Mechanism: Quercetin, a flavonoid found in many fruits and vegetables, has multiple bioactive effects, including antioxidant, anti-inflammatory, and antiviral properties.
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Antioxidant Action: Neutralizes free radicals, reducing oxidative stress and protecting cells.
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Anti-inflammatory Action: Inhibits inflammatory pathways and reduces cytokine production.
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Antiviral Action: Interferes with viral replication by blocking viral entry and modulating host cell responses.
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Indirect Protease Inhibition: While not a direct protease inhibitor, quercetin may affect viral protease activity indirectly by modulating cellular pathways involved in viral replication. This can influence the processing of viral proteins necessary for replication.
- Cautions: High doses may cause gastrointestinal discomfort.
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- Anthelmintic Properties
Wormwood (Artemisia absinthium)
- Mechanism: Contains artemisinin and other compounds with antiviral and antiparasitic properties. It may interfere with viral replication and modulate immune responses.
- Dosage: Typically 200-400 mg/day of standardized extract. For acute treatment, dosages may vary, and professional guidance is essential.
- Toxicity: Generally safe in recommended doses. High doses may cause nausea, vomiting, or neurological effects. Prolonged use can be toxic.
- Cautions: Combining wormwood with anthelmintics like ivermectin or fenbendazole may increase the risk of adverse effects or toxicity. Wormwood may also interact with drugs metabolized by the liver’s cytochrome P450 system.
Garlic (Allium sativum)
- Mechanism: Contains allicin, which has antimicrobial, antiviral, and anthelmintic properties. It supports immune responses and disrupts the metabolism of pathogens.
- Dosage: 600-1,200 mg of aged garlic extract daily. Acute treatment might involve higher doses with medical advice.
- Toxicity: Generally safe. High doses may cause gastrointestinal upset, heartburn, or allergic reactions.
- Cautions: Garlic can enhance the effects of anticoagulants (e.g., warfarin), increasing bleeding risk. Use with caution if on blood thinners or undergoing surgery.
Black Walnut (Juglans nigra)
- Mechanism: Contains juglone, which exhibits anthelmintic and antimicrobial properties. It disrupts the metabolic processes of parasites and pathogens.
- Dosage: Typically 500-1,000 mg/day in extract form. Acute treatment dosages should be managed by a healthcare provider.
- Toxicity: Generally safe but can cause gastrointestinal discomfort. High doses may lead to liver toxicity and allergic reactions.
- Cautions: Black walnut may interact with anticoagulants and medications metabolized by the liver. Caution is advised if taking other drugs that affect liver metabolism.
Ivermectin
- Mechanism: Binds to parasite muscle and nerve cells, causing paralysis and death. Ivermectin may also exhibit some antiviral effects by inhibiting viral replication.
- Dosage: Typically 150-200 µg/kg body weight, administered as a single dose. Dosage may vary based on specific indications and should be adjusted according to clinical guidance.
- Toxicity: Generally well-tolerated. High doses or prolonged use may cause dizziness, gastrointestinal issues, or neurological effects.
- Cautions: Caution advised when used with other medications that affect liver enzymes, as it can interact with drugs metabolized by cytochrome P450.
Fenbendazole
- Mechanism: Disrupts the parasite’s microtubule formation, leading to its death. Fenbendazole also has potential antiviral effects by affecting viral replication.
- Dosage: Commonly 10-50 mg/kg body weight per day, typically for 3 days. Dosage may vary based on clinical indications.
- Toxicity: Generally safe at recommended doses. High doses may cause gastrointestinal upset or liver issues.
- Cautions: Use with caution if combined with other drugs that affect liver metabolism. Limited data on interactions with other medications.
Purchase Links from what I take and know works.
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- Nano Cucumin: https://a.co/d/cACbW0s
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- Nano EGCG: https://a.co/d/1ccmzo6
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- Nano Quercetin: https://a.co/d/b7LT41d
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- Fenbendazole: https://fenben.pro/product/fenbendazol-powder/
Thank you for your thoughts. -Christianity teaches that moral truth is objective and grounded in the unchanging nature of God, rather than being relative or shaped solely by evolutionary processes. Morality is the very nature of God and what Christians use to determine what is good, bad, or immoral. In other words, Gods nature is the foundational truth of what morality is. While human brains and moral intuitions have evolved, Christianity argues that true morality cannot be fully explained by evolution or survival of the fittest alone. Instead, moral law reflects God's eternal nature and is revealed through Scripture, providing a consistent standard of right and wrong. This divine moral framework complements and transcends natural moral insights, offering a unified and enduring guide to genuine freedom and flourishing.
- Christianity distinguishes between general revelation and special revelation. General revelation refers to the moral insights and truths evident in nature and human conscience, which reflect God’s eternal law and provide a basic understanding of right and wrong. Special revelation, on the other hand, is the more detailed and explicit disclosure of God's will and moral teachings found in Scripture and the life of Jesus Christ.
From what i know of Dawkin's
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Richard Dawkins argues that morality predates religion, including Christianity, suggesting that pre-Christian societies were moral based on evolved social behaviors. He believes Christianity absorbed existing cultural practices rather than creating morality. Roman and Greek thought significantly influenced Christian doctrine, blending with older moral codes rather than supplanting them.
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Dawkins would reject the notion that ancient tribes like the Saxons or Vandals were immoral, instead emphasizing that morality varies by context and evolved across all human societies.
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Regarding perception and energy, Dawkins, a proponent of scientific skepticism, would be critical of spiritual or metaphysical claims unsupported by empirical evidence. While acknowledging energy's foundational role in physics, he would reject supernatural interpretations.
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On indoctrination, Dawkins strongly opposes religious education that imposes dogma on children. He advocates for fostering critical thinking and intellectual freedom, emphasizing reason and evidence over tradition and religious authority.
My own views
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From a Christian perspective, the moral codes of pre-Christian societies were shaped by natural law, a reflection of God's eternal law written on the hearts of all people. While these societies exhibited moral behavior, Christianity introduced a transformative ethic centered on Christ's teachings of love, forgiveness, and the sanctity of every individual, fulfilling and transcending earlier codes.
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Christianity did not simply adopt the morals of various tribes and regions; it redefined them in light of divine revelation. Roman and Greek thought, particularly in philosophy and ethics, influenced Christian theology, enriching its intellectual foundation. However, Christianity uniquely emphasized humility, mercy, and self-sacrificial love, values that were less emphasized in classical philosophy.
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Regarding the morality of ancient tribes like the Saxons, Goths, or Gauls, Christianity acknowledges that all people, created in the image of God, have the capacity for good. Yet, like all humanity, they were in need of redemption through Christ. Ignorance, in this context, is not merely a lack of knowledge but a spiritual blindness that can lead to the rejection of truth. Christianity offers a path to overcome this ignorance through faith, grace, and the transformative power of Christ's teachings.
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Ultimately, Christianity encourages individuals to seek truth, not merely through their own authority but through the guidance of divine wisdom, as revealed in Scripture and the teachings of the Church. The goal is not control but freedom—the freedom that comes from living in accordance with God's eternal law, which leads to true life, liberty, and the pursuit of holiness.
No, it doesn't my argument stems from listening to every one of his debates and reading every one of his books. He does not believe that God exists and would not follow him if he did.
Even if there were a God, it would be a far more admirable thing to say no to that god and to be an atheist out of moral conviction.
He has stated that believing in God is akin to believing in a "sky fairy" and has compared religious indoctrination of children to child abuse, suggesting that teaching children about hell is psychologically damaging.
So, no its not out of ignorance its out of knowledge of what he has said to believe.
Nano-Phytochemicals and drugs for Lung Cancer and Brain Metastasis
EGCG (Epigallocatechin Gallate):
- Mechanisms:
- EGFR Inhibition: Reduces lung cancer cell growth by blocking EGFR signaling.
- Antioxidant: Decreases oxidative stress and DNA damage.
- Anti-Angiogenesis: Inhibits VEGF, reducing blood supply to tumors.
- Cell Cycle Arrest: Causes G1 arrest by modulating CDKs.
- Synergy with Chemo/Immunotherapy:
- Chemo: Enhances chemotherapy efficacy by inhibiting DNA repair mechanisms, making cancer cells more susceptible.
- Immuno: EGCG may enhance immune responses by reducing tumor-induced immunosuppression, potentially increasing the effectiveness of immune checkpoint inhibitors.
- Nano-formulation:
- Nano EGCG: Enhances stability, bioavailability, and BBB penetration for targeted tumor delivery.
- Nano-EGCG link
Quercetin:
- Mechanisms:
- Apoptosis: Induces cell death through caspase activation and mitochondrial pathways.
- Anti-Metastasis: Reduces cancer invasion by inhibiting MMPs.
- Anti-Inflammatory: Suppresses cytokines like IL-6 and TNF-α.
- P-gp Inhibition: Enhances drug retention by inhibiting P-glycoprotein.
- Downregulation of Glycolysis: Quercetin can disrupt cancer metabolism by inhibiting key enzymes in glycolysis, leading to reduced energy production in cancer cells.
- Synergy with Chemo/Immunotherapy:
- Chemo: Increases chemotherapeutic efficacy by enhancing drug retention and disrupting cancer metabolism.
- Immuno: Anti-inflammatory effects may reduce tumor-associated immunosuppression, improving immune response.
- Nano-formulation:
- Nanomicellar Quercetin: Enhances solubility, bioavailability, and BBB penetration for effective targeting of lung tumors and brain metastases.
- Nano Quercetin link
Curcumin:
- Mechanisms:
- NF-κB Inhibition: Reduces inflammation and tumor growth by blocking this key pathway.
- Apoptosis: Promotes cell death by upregulating p53 and downregulating Bcl-2.
- Anti-Angiogenesis: Inhibits VEGF to reduce tumor blood supply.
- P-gp Inhibition: Curcumin may also inhibit P-gp, similar to quercetin, improving drug retention.
- Downregulation of Glycolysis: Curcumin can inhibit glycolysis, reducing the energy supply to cancer cells and making them more vulnerable.
- Synergy with Chemo/Immunotherapy:
- Chemo: Sensitizes cancer cells to chemotherapy by disrupting survival pathways, glycolysis, and enhancing drug uptake.
- Immuno: May reduce tumor-induced immunosuppression, complementing immunotherapies.
- Nano-formulation:
- Liposomal/Nanocurcumin: Increases solubility and bioavailability, improving penetration into lung tumors and brain metastases.
- Nano Cucumin link
Resveratrol:
- Mechanisms:
- PI3K/AKT Inhibition: Disrupts a critical survival pathway, reducing cancer cell growth.
- Autophagy Induction: Promotes autophagic cell death in cancer cells.
- Anti-Metastasis: Inhibits EMT and MMPs, reducing cancer spread.
- Antioxidant: Lowers oxidative stress, potentially reducing mutation rates and tumor progression.
- Downregulation of Glycolysis: Resveratrol inhibits key enzymes in the glycolytic pathway, thereby reducing cancer cell energy production.
- Synergy with Chemo/Immunotherapy:
- Chemo: Enhances chemotherapeutic effects by disrupting cancer metabolism and survival pathways.
- Immuno: Its antioxidant and anti-inflammatory properties may create a more favorable environment for immune responses.
- Nano-formulation:
- Nanoencapsulated Resveratrol: Improves bioavailability, stability, and targeting of lung tumors and brain metastases.
- Nano Resveratrol Link
Fenbendazole (P-glycoprotein Inhibitor):
- Mechanisms:
- P-gp Inhibition: Prevents drug efflux, increasing intracellular concentrations of chemotherapeutic agents.
- Apoptosis: Disrupts microtubules, leading to cancer cell death.
- Downregulation of Glycolysis: Fenbendazole inhibits key enzymes in the glycolytic pathway, reducing cancer cell energy production and survival.
- Synergy with Chemo/Immunotherapy:
- Chemo: By inhibiting P-gp and glycolysis, fenbendazole increases the effectiveness of chemotherapeutic drugs, especially in drug-resistant cancer cells.
- Immuno: Although primarily synergistic with chemotherapy, its effects on glycolysis and microtubule disruption may make tumors more vulnerable to immune attacks.
- Nano-formulation:
- Nano-fenbendazole: Enhances delivery and absorption, improving efficacy against drug-resistant lung cancer and brain metastasis.
- FenBenPro Link
- 1000mg 3 times a week. 1 week off after 3 weeks.
- Drink lots of water as it can cause liver toxicity when dehydrated.
Here is a chart I have made showing the intracellular pathways of Non small cell lung cancer, and what chemicals inhibit what pathways of the cancer.
I will help you but I need answers
- what specific type of cancer.
- what stage
- What are his mutations
- is he on the standard of care or only palliative?
- what is his pdl1 levels (if applicable)
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What level of medical information would you be comfortable with?
- detailed and advanced
- topical and intermediate
- minimal and simple.
Was this her first time being pregnant?