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Biologyfag here. Not an immunologist, but I play one on TV. Putting together a couple of bits of data here…
p. 1:
- Internal Pfizer vaccine study from Japan, available on government regulator's website (attached for posterity, but for your safety and peace of mind you can get it from them):
https://www.pmda.go.jp/drugs/2021/P20210212001/672212000_30300AMX00231_I100_1.pdf
- Reuters "Fact Check":
“We can confirm the document does not make any reference to spike proteins from the vaccine resulting in dangerous toxins that linger in the body – this claim is incorrect”, the spokesperson said.
- https://byrambridle.com "fact check" website (NOT Dr. Bridle's website.)
"There is no spike protein in the mRNA vaccines:"
All true. There is (purportedly) no spike protein in the vaccine itself. But what does the mRNA in the vaccine do?
- (image attached) 48-hour mRNA lipid nanoparticle concentration in Wistar rats, from 1), table 2.6.5.5B.:
The mRNA is packaged in lipid (fat) nano- (extremely small) particles in the jab. The Pfizer document contains measurements of the concentration of these lipid nanoparticles in different organs and tissues in Wistar rats over time, from 15 minutes to 48 hours after injection. In other words, they jabbed a bunch of literal lab rats, "sacrificed" that means killed 1 out of 7 of them after 15 minutes, and the same number after 1 hour, 2 hours, 4 hours, 8 hours, 1 day, and 2 days. Then they dissected them, likely pureed the pieces, and used some sort of radiation sensor to measure the concentrations of tritium (radioactive hydrogen) put into the nanoparticles beforehand.
The concentration of particles still found at the injection site after 48 hours was 165 micrograms (µg) per milliliter (mL). An equivalent measure would be milligrams per Liter. To give an idea of the ratio, a Liter is a bit more than a quart, and 1000 grams (a kilogram) is about 2.2 pounds. A (very) loose translation of the ratio of 165 mg/L is 165 parts per million. 165 parts per million doesn't sound like a lot, but remember, this is for whole tissue. 1 million / 165 is one part in 6060, for everything in the tissue, extracellular stuff, cell membrane, intracellular stuff, and a bunch of water. It's a lot.
What happens to the lipid nanoparticles over time after injection? From 15 minutes to two hours, they become detectable in their highest concentrations over time at the injection site (394 mg/L after 1 hour), and in Whole blood (w/red and white blood cells, 5.40 mg/L) and Plasma (just the liquid part, 8.90 mg/L) after 2 hours, where the plasma makes up a bit more than half of the blood volume. They also reach significant concentrations after two hours in the Liver, Spleen, and Kidneys, which are likely attempting to filter/degrade/detoxify/remove them. While 8.90 in the blood after 2 hours seems a lot smaller than 394 at the injection site after 1 hour (311 mg/L after 2 hours), remember that the volume of the injection site is much smaller than the volume of the blood in the rat. Without looking up the average blood volume of mature male/female Wistar rats, it is safe to say that a very large fraction of the injected nanoparticles do not stay at the injection site.
Over the next 48 hours, the concentration at the injection site goes down by about half, the concentration in the blood goes down, and the concentrations in the Liver and Spleen continue to go up. This means that nanoparticles from the injection site continue to leave the injection site, carried away predominantly in the blood plasma, whence they are free to enter cells in other tissues. The fact that the blood concentration continues to go down even as lipid nanoparticles are being released from the injection site further underlines the difference in volume between the injection site and blood. Aside from the injection site, the highest organ concentrations after 48 hours are in the Liver and Spleen.
p. 2
Here's where it gets interesting (as if the above weren't utterly fascinating to begin with.) The next highest concentration over time is in the Ovaries (in the females, of course.) The concentration continues to go up continuously over the 48 hour span. Why? Unknown, although there are two main possibilities. First, it is possible that cells in the ovary express some surface molecule that happens to have an affinity for the particular lipid molecule that makes up the volume of the mRNA-containing nanoparticles. Second, it is theoretically possible that the lipid nanoparticles have been tagged with surface molecules that (intentionally or unintentionally) happen to have an affinity for surface molecules on cells in the ovary. Either possibility seems bad.
- Adaptive immunity, B cells and T cells:
And so, we come to the type of tissue that is point of this flapper-worthy raft of text. The next highest 48-hour concentration is in the Bone Marrow. This is where new blood cells are made. The concentration is 3.77 mg/L or (very loosely) about 3.7 parts per million, a ratio of about 1 part in 265,000. Again, this may not seem like a lot, but only one lipid nanoparticle needs to get into a cell to deliver its payload. There are all kinds of cells in the bone marrow, stem-like cells, and other more mature cells that those divide into. In particular, this is where new B and T cells are made. These largely constitute what is known as the "adaptive" immune system.
B and T cells are special because they have molecules on their surface that are different for each one, billions of cells over. It is all these different "sticky ends", called receptors, on them that make B and T cells stick to molecules the body has never "seen" before, like those from bacterial, viral or toxin invaders. And yet the human genome does not have a separate "gene" for each of these billions of possibilities. The diversity of the adaptive immune cells is made possible by a process called V(D)J recombination. The V, D, and J represent the genomic forms of the sticky ends of the B and T cell surface molecules. This part of the genomic DNA that makes up the genes involved is in every cell in the body, but is only "turned on" in B and T cells that are recombining them to make their unique sticky ends. Pretty cool, actually.
Mature B cells go off into the blood to look for Bad Things (called antigens) floating around. If they find something that they stick to well enough, they begin dividing (and dividing, and dividing), making 2, 4, 8, 16, 32…1024768 copies, all of which have the same sticky-ended molecules, just like the cell that originally stuck to the Bad Thing. At some point, these B cells begin to manufacture bits of protein that also look like their sticky surface molecules, but are released from the cell into the bloodstream. These are called antibodies. Antibodies stick to the same thing the original, unique B cell stuck to. With trillions of identical copies of them floating around, however, they will stick to everything identical to what the original cell stuck to. Other types of killer cells can "see" something that has a bunch of antibodies stuck to it, and will come along and grab them to absorb, neutralize, and remove the offending invader. Finally, after a matter of days, this new population of B cells will decline, but some stay around long-term to become "memory" B cells, available to deal with the same threat in the future, in numbers still way larger than the lone B cell that originally sounded the alarm. The ramp-up in B cells takes hours/days, and this is why it takes time to get over an infection, and the memory cells keep you from getting sick from the same infection twice.
p.3
T cells are very similar, but they're not looking for things outside of our cells they're looking for clues to things inside of our cells that aren't supposed to be there. How can they do this from the outside? The answer lies in molecules that are expressed on the surface of every cell in the body, the Major Histocompatibility Complex (MHC) molecules. These molecules grab onto tiny bits of proteins inside the cell that have outlived their usefulness and have been broken down into small pieces called "epitopes". The MHC molecules with epitope attached then find their way to the surface of the cell, where T cells can "see" them. The magic of how no B or T cells are made/kept that stick to "self" is way too much to deal with here, but a breakdown in this process, where they incorrectly attack the body's own tissues, is called an autoimmune disease. Suffice it to say, however, that when a T cell comes along and sticks to an epitope/MHC on the outside of one of our cells, it's because the epitope came from something on the inside (like a virus) that shouldn't be there. (This is also why organ donors and recipients are tissue typed by their MHCs a mismatch in these will cause every cell from the donor to look like a foreign invader.)
Continued in comments, up-Q for continuity?
CONTINUED
Okay. We've now gotten enough about adaptive immunity to explain the following paper released on Oct 13, 2021.
https://www.mdpi.com/1999-4915/13/10/2056
This paper looks at the intracellular distribution of the various bits that make up the SARS-CoV-2 virus. In general, a virus has a bit of DNA or RNA inside it that encodes the proteins that make up the shell (capsid) and surface (spike) proteins for the virus, but no machinery to take that code and translate it into those proteins itself. For that, it has to get the DNA or RNA (RNA in the case of Covid-19, and Coronaviruses in general) inside the cell, where it can highjack the cell's own machinery to make thousands of copies of itself, the capsid, and spike proteins, usually destroying the cell in the process. This paper looks at what happens when cells make the different types of bits for the Covid viral capsid and spike protein(s), and where those bits end up in the cell. Of all the different bits, one of these localizes predominantly in the cell nucleus – the Covid spike protein.
The paper then looks at what the spike protein does when it gets to the nucleus. The nucleus is the “library” for the cell, where all the human genomic DNA resides, and molecular “librarians” control the dispatch of copies of protein-coding genes out into the cell as messenger RNA (mRNA), to be translated into proteins that do all kinds of things. The spike protein, as it turns out, is the unwelcome library patron that interferes with the librarians in the performance of their duties. Specifically, it interferes with two “DNA repair” processes known as non-homologous end joining (NHEJ) DNA repair and homologous recombination (HR) DNA repair.
p. 4
In V(D)J recombination, the process inside immature B and T cells that creates the unique sticky ends for the outside of that cell for it to become a mature B or T cell, the V, D, and J parts of the gene for the sticky part are taken apart, modified, and put back together. This process has some randomness to it, which is where the billions of different resulting combinations arise for each unique B or T cell receptor. If “taking bits of genes apart, modifying them, and putting them back together, with randomness involved” sounds complex and scary, well, it is. If it doesn’t quite work out, the cell generally doesn’t make it. NHEJ DNA repair is necessary for the “putting them back together” part. If NHEJ is kept from happening in a maturing B or T cell, that’s a problem. If it happens in a lot of maturing B and T cells, it’s a recipe for disaster.
Let’s follow the mRNA in the injections: It is contained in lipid nanoparticles, which are generally injected into the deltoid muscle of the upper arm. Those lipid nanoparticles do not overwhelmingly stay there, but enter the bloodstream. A nontrivial concentration of them ends up in the Bone Marrow. The mRNA in the lipid nanoparticles finds its way into developing blood cells in the bone marrow, some of which are immature B and T cells.
In all types of cells, the mRNA from the injection is translated into Covid-19 spike proteins, some of which are supposed to then get back to the bloodstream, where naïve (mature, but have never seen their antigen soulmate and started dividing to churn out progeny) B cells can say “whoa there, fella”, and make antibodies for the spike protein, which ostensibly confers some humoral (plasma antibody) immunity to the virus. Other spike proteins, however, find their way to the cell nucleus, since that’s where they seem to like to congregate.
Once in the nucleus, the spike proteins inhibit two DNA repair processes crucial to the continued integrity of every cell. For immature B and T cells in the process of undergoing V(D)J recombination, the spike protein keeps this from being successful by inhibition of one of the two processes. If this happens often enough, few new B or T cells make it to maturity, and out in the bloodstream where they can look for skullduggery. For all cells, genomic errors left unrepaired due to the failure of these repair process will eventually lead to serious issues within those cells and the cells that result from cell division.
A shortage of B and/or T cells is an immunodeficiency, one manifestation of which we know of as AIDS. Cells with cascading genomic errors leading to mis-regulated cell destruction and division fall into the category of what we know of as Cancer.
First - thank you for taking the time to write this out. It's a very helpful and detailed review.
For anyone who wants a video explanation of the VDJ process, i reccommend this video which gives an excellent overview accessible to the layperson;
https://www.youtube.com/watch?v=-SYL-iU0E9Q
OP, what you have pulled together here is also making alarm bells ring for me, as I saw a couple of months ago some blood-work slides that seemed to be indicating the presence of not fully formed white blood cells in the blood of (i think) vaccinated patients. Do you think this might be connected?
It sounds like the Bärbel Ghitalla & Axel Bolland's presentation.
https://www.bitchute.com/video/iNeJFqQ0TxYS/
I don't know if it's connected.
Thank you u/nukyalur for your outstanding post! 👏
Bless you for sharing here. 🙏
One thing that isn't clear in your description.. I think the LNPs that end up in the liver, etc after 48 hours are the "empty packages"... That is they probably already delivered the payload and then float around. They can only be metabolized in the liver so that's where they need to end up. But it's not clear if they do end up there or how long it takes. More than 48 hours apparently. To me this is a potential cancer risk of they don't go away.
Let me preface this question by saying that there is no freaking way I want to have this shit injected in me. I will probably get fired when Brandon's company size >100 bullshit kicks in in January assuming the temporary stay is eventually knocked down by yet another DS judge. The OP's posts about the 48 hour study are alarming and the fact that the long term is unknown scares the shit out of me for my friends and family who ignored my advice and got the clot shot.
I am a homebrewer . I know that the Amylase enzymes in malts break the starches down into sugars so that they can be fermented by the yeast into beery goodness.
I was told (by a pro-"vax" pro brewer in a heated exchange with him over clot shot safety) that there is an analogous enzyme that breaks down mRNA in our bodies and that that enzyme is supposed to remove the mRNA from a "vaxxed" person's body to eliminate the spike protein mRNA from the injection. I have not been able to find anything on that topic anywhere. Is that true or is it BS? Do "vaxxed" bodies perpetually produce this shit or does it get degraded out like he says it does?
My intuition tells me it is probably something in between -- some gets degraded out but somehow our body produces more of the spike protein mRNA so it never goes away. But, I am an engineer, not a biologist, so honestly, I don't know what is true or not.
Thank you so much for sharing this. Took me forever to get through it but it was worth it.
Am I correct in understanding that the harm described above is completely unrelated to ADE?
EDIT: My thinking from this would be that just as Ivermectin helps your body in multiple ways, the spike protein damages it in multiple ways: antibody dependent enhancement, vascular damage, and immune system destruction.
Yeahhh....
I'm going to need this in video form...
TLDR Vaccine can cause AIDS and/or cancer
...and Ivermectin has been shown to treat and cure cancer
Hopefully there's a way out of this then. The idea of the majority of the planet dying along with most of my loved ones is not a pleasant one.
You won't get AIDS specifically if you're vaxxed. But the T and B cells will become immunodeficient and it will be like having AIDS in that a small sickness could take you out.
Is there ANY practical reason to insist on making this distinction? I see none, in fact it is counterproductive and confusing. Just call it AIDS. What does AIDS stand for? Autoimmune diseases syndrome or something? Seems to fit the bill.
AIDS an be spread through bodily fluids, sexual transmission, and from mother to child during pregnancy, delivery or breastmilk. There is not enough evidence yet to know if the effects of the vaccine can be spread through these means.
Is AIDS defined by the way it is spread though? I'm thinking not.
Of course it is. Does it matter or not if someone has had a blood-transfusion taken from a vaccinated person? Is this AIDS-like symptom permanent or temporary? Is this disease going to spread via sexual transmission? If it is permanent and spreads the same as AIDS and has all other defining markers as AIDS, then it is AIDS. If it does not, then we should specify that by calling it something different. Definitions and distinctions are important and changing them to suit a narrative is what they do. For example, the CDC changing the definition of 'vaccine'.
Exactly. I looked it up. You are said to have AIDS if the following takes place: -the number of their CD4 cells falls below 200 cells per cubic millimeter of blood (200 cells/mm3). (In someone with a healthy immune system, CD4 counts are between 500 and 1,600 cells/mm3.) OR -they develop one or more opportunistic infections regardless of their CD4 count.
there is nothing here about method of transmission. If this is something the clot shot does to you, then you have AIDS.
According to clinicalinfo .gov this is the definition of AIDS:
To be diagnosed with AIDS, a person with HIV must have...
One must have HIV to be diagnosed with AIDS.
What is HIV?
It is possible to have low CD4 count and not have AIDS. According to webmed:
TLDR: The defining factor for AIDS cannot solely lie on white blood cell (CD4) count. One must have HIV as well.
According to whom?
Ok, that's fair, but I feel like it's too strong a word to give up. Peoples lives WILL be saved if we spread the idea that the shot can give you aids, they can fact check us but connecting it with the idea of AIDS is something I will continue to do.
Succinct and concise recap. Nice.
This is an excellent overview. I would like to add my own worries regarding the T cell response to this madness. As you said, T cells react to foreign epitopes on the MHC molecules. This so called vaccine will force every cell that takes up the foreign mRNA to produce spike protein, which is a huge concern in and off itself, but this will also make the cell present spike epitopes on its MHC, targeting it for destruction by CD8 T cells. As it seems the mRNA from the vaccine spreads to pretty much everywhere, it could cause autoimmune reactions in every organ of the body. Its surprising to me that none of the so called experts have anything to say about the T cell response to these vaccines, as T cells are the most important cells in a viral infection. But then again, maybe not that surprised.
Over my head. Now play reverse researcher and figure how to reverse and clean up damage. In my heart I know it can be done with God's help.
This is where our collective minds need to be focusing on. There has to be a way to undo the damage, or least stop it from doing anymore damage.
Agreed! I have not specifically prayed for a reversal strategy to get into the right hands, but I will now. Who will join me?
Thanks, OP!
Joining you in prayer fren! 🙏
“I also tell you this: If two of you agree here on earth concerning anything you ask, my Father in heaven will do it for you. For where two or three gather together as my followers, I am there among them.” Matthew 18:19-20 NLT https://bible.com/bible/116/mat.18.19-20.NLT❤😁🙏
AMEN! So MANY wonderful gifts from Our Father! Knowing He is ALWAYS with us!
Blessings fren!
This is the most disturbing part and should scare there hell out of everyone:
"SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro"
If you know anyone with the BRCA gene defect (AKA the breast cancer gene), then you know they are almost guaranteed to get breast, ovarian, pancreatic, melanoma, and other cancers. Why? Because when the BRCA gene is defective, it cannot identify, remove, and repair any mistakes made during DNA replication as cells divide. If a mistake is made in the DNA, that mistake becomes a permanent part of the cell genome and is propagated in that particular cell line for the rest of the person's life. Hence, unfixed mistakes occurring in the genomic region responsible for cell growth leads to uncontrollable growth and tumor formation.
So if the presence of spike protein in the nucleus inhibits repair of damaged DNA, then it essentially mimics what having a defective BRCA gene does. Therefore, you can surmise that vaccinated people have now inadvertently been turned into a kind of BRCA patients.
Since it seems like the spike protein accumulates in ovarian tissue and bone marrow, I wouldn't be at all surprised to see a large increase in leukemia, lymphoma, and ovarian cancer pretty soon.
Pure Evil
Is the spike production and expression long lasting? How long would it last (no boosters) ?
Great question. Not sure. Trying to find any papers that have evaluated. And there are papers about mRNA gene therapy in pancreatic cancer (but that's used to replace a gene that should have been there all along; not introduce something new and non-native). But I think the bigger question is how much damage can it cause while it is around. Whatever damage can not be spliced out and corrected will be propagated in that cell line forever. I'm wondering if regardless of whether the spike doesn't stay long, will there still be lasting effects of when it was there that result in cancer. And if so, how long will it take to show up. Some increases in cancer are already being seen, and this is because some cancers are a result of a poor immune system (like AIDS as some studies suggest). So wave 1 cancers will be the result of immune cells not killing defective cells that are already present. And we've 2 will be from defective DNA replication and uncontrolled new cell growth of the mistake occurs somewhere in the growth regulation part of the genomic code. That's my hypothesis.
Well done, excellent presentation of detailed info
Loved it! Thank you so much for taking the time to write this down. Is not easy to catch many of the implications of those kind of drug tests.
Excellent info thanks.
Excellent breakdown of the process. Thank you for the post.
When this particular study broke, it sent some shock waves through scientific circles paying close attention to information regarding the immune effects of these jabs. Beyond the immediate vascular and neurological effects of these inoculations, that are devastating on their own, what is even more frightening is the long term immunological and reproductive effects looming on the horizon. By the time some of these significant pieces of the puzzle are finally put together enough to give us a picture of the processes at work, it will be too late for far too many - the damage will have been done.
This study is one more piece of evidence that points to the nightmare scenario of the destruction of the human innate immune response that not only will increase autoimmune disease, but may leave a huge portion of the world's population unable to deal with even the most benign illnesses like the common cold. Add to this, the mutagenicity risks of some of the antiviral drugs being developed by Merck and Pfizer, and we are looking at some serious catastrophic biological nuclear bombs that have the potential to kill millions by a slow and painful death - all while making the designers and manufacturers of these poisons massive profits on the backs of untold human suffering.
Why do some authors refer to COVID19 as "reverse AIDS"?
Thank you for this. I now have more info to add to my arsenal. Well written and easy to comprehend.
Thank you for taking the time to break this down.
I did not know the mechanics of it, but intuited from what I could grasp that cancer, autoimmune and immune deficiency were the real threat of this injection.
Their own explanations for the jab suggested this (to me), but I could not have extrapolated so effectively the process described in the paper.
Really, thanks much for your hard work!
Post is gold. Thank you for putting all this together OP.
this seems to support the findings from the Spartacus letter - this is a hematological (blood related) disease, not originating at the respiratory system according to the MSM
Forgive me, buddy. I was passing this on. OG BioFag said this across four posts on the 8kun, and I thought It was worthy of sharing.
I'll take it!
Ty fren! Very interesting
Really awesome post nukyalur. As the real picture comes together real Justice will hopefully be served, eventually. Sooner the better.
Very well written for non-biologists! Thank you!! Keep writing and send moar!! Oh, there is moar!!
Anyone who knows a diabetic can tell you that the particles will not stay at the injection site. Insulin is injected into interstitial fluid and yet it gets into the blood stream in order to reduce blood sugar. That happens quickly. Our bodies are great at transporting things quickly throughout the body. Give a diabetic sugar and watch their blood sugar spike in a mater of minutes.
Pfizer safe, take it.