Yes, the methylcobalamin form does not need to be converted before absorption. Cyanocobalamin is the form of B12 that creates a cyanide molecule during its conversion to be absorbed. Not good, though it’s in almost every B supplement on the market. Good news-Costco started carrying methylcobalamin for under $20 for 300 sublingual tabs.
Ok, so it's true about the paucity of actual genetic diseases. But Methylation is highly misunderstood, especially in functional medicine. There are numerous errors in that space regarding methyaltion and SNP's. Well it depends, they are not errors if you are selling and profiting off the incomplete information. But for patients the deep dive is important:
Oxygen is the terminal electron acceptor (almost exclusively), and those with methylation defects are taking pills or supplements that may not do a thing to their methylation pathways, until they fix the redox problem in their mitochondria. Redox shifted mitochondria affect both ends of the ECT (electron chain transport). The rostral end in ECT is the NAD+/NADH couple, and the distal end is in oxygen delivery to ECT to accept electrons that have been passed down through ECT, and had their light energy harvested as they move from cytochrome 1 to 5.
In 2013 the landmark paper by David Sinclair linked low NAD+ and pseudohypoxia to aging. It is now known that Pseudohypoxia and low oxygen tension cause methylation defects. Most functional medicine doctors have NO IDEA this is true. Nor do they realize that hypoxia can make up 50% of the methylation defects.
Oxygen levels are in fact linked to solar exposure, because UV light catalyzes oxygen production in the atmosphere via ozone. Cells also release ELF-UV and this can affect TET enzymes and endogenous methylation cycles in a cell.
This means that improving your solar exposure ALONE can repair most methylation defects in people with uncoupled mitochondria with poor SNP's. Very few people get this information provided. Instead, they are sold tests, supplements and pills to repair themselves. That is impossible when their mitochondria are still redox shifted and pseudo hypoxic. It is most likely that the presence of methyaltion defects is indicating redox shifted mitochondria, and at root the person is simply not getting enough sunlight. TET enzymes catalyse DNA de-methylation through 5-methylcytosine oxidation. TET = oxygen-dependent Ten-Eleven Translocation enzymes.
Fix the MITOCHONDRIA defect which pills and supplements can't fix. You won't hear about the best fix from allopathic medicine, functional medicine, or even most alternative medicine. Because it involves light frequencies, and you can't patent or sell light frequencies. The sun is already there as nature's compound pharmacy, humans simply have to relearn how to use it.
Excellent breakdown fren and I concur with your assessment. Yes, something as simple as sunlight is not profitable for those wanting to sell some fix in a bottle.
Having the proper mindset, and thoughts can fix a lot issues. Get out to get some fresh air and sun also does wonders. An occasional fast (24 - 72 hours) is also good for the body.
@smartbaum sums it all up pretty well. Methylation is a poorly understood process and it seems that alternative health practitioners are just now jumping on the bandwagon seemingly without understanding the underlying science - just as our fellow anon has stated. Supplements alone cannot fix some of these underlying problems with mitochondrial dysfunction. Once again, light and other frequencies can have healthful or deleterious effects on how the body functions. It is hard to make money on sunlight. Thanks
It's the truth! I take 15mg of methylfolate and 1mg of methycobalamin everyday because of this MTHFR.
I have MTHFR, too. I take methylfolate and will look for the other.
Methylcobalamin is the active form of Vitamin B12.
Thanks!!
Yes, the methylcobalamin form does not need to be converted before absorption. Cyanocobalamin is the form of B12 that creates a cyanide molecule during its conversion to be absorbed. Not good, though it’s in almost every B supplement on the market. Good news-Costco started carrying methylcobalamin for under $20 for 300 sublingual tabs.
Thanks good to know!
Ok, so it's true about the paucity of actual genetic diseases. But Methylation is highly misunderstood, especially in functional medicine. There are numerous errors in that space regarding methyaltion and SNP's. Well it depends, they are not errors if you are selling and profiting off the incomplete information. But for patients the deep dive is important:
Oxygen is the terminal electron acceptor (almost exclusively), and those with methylation defects are taking pills or supplements that may not do a thing to their methylation pathways, until they fix the redox problem in their mitochondria. Redox shifted mitochondria affect both ends of the ECT (electron chain transport). The rostral end in ECT is the NAD+/NADH couple, and the distal end is in oxygen delivery to ECT to accept electrons that have been passed down through ECT, and had their light energy harvested as they move from cytochrome 1 to 5.
In 2013 the landmark paper by David Sinclair linked low NAD+ and pseudohypoxia to aging. It is now known that Pseudohypoxia and low oxygen tension cause methylation defects. Most functional medicine doctors have NO IDEA this is true. Nor do they realize that hypoxia can make up 50% of the methylation defects.
Oxygen levels are in fact linked to solar exposure, because UV light catalyzes oxygen production in the atmosphere via ozone. Cells also release ELF-UV and this can affect TET enzymes and endogenous methylation cycles in a cell.
This means that improving your solar exposure ALONE can repair most methylation defects in people with uncoupled mitochondria with poor SNP's. Very few people get this information provided. Instead, they are sold tests, supplements and pills to repair themselves. That is impossible when their mitochondria are still redox shifted and pseudo hypoxic. It is most likely that the presence of methyaltion defects is indicating redox shifted mitochondria, and at root the person is simply not getting enough sunlight. TET enzymes catalyse DNA de-methylation through 5-methylcytosine oxidation. TET = oxygen-dependent Ten-Eleven Translocation enzymes.
Fix the MITOCHONDRIA defect which pills and supplements can't fix. You won't hear about the best fix from allopathic medicine, functional medicine, or even most alternative medicine. Because it involves light frequencies, and you can't patent or sell light frequencies. The sun is already there as nature's compound pharmacy, humans simply have to relearn how to use it.
Excellent breakdown fren and I concur with your assessment. Yes, something as simple as sunlight is not profitable for those wanting to sell some fix in a bottle.
I think I followed as far as SNP's but what does methyaltion have to do with belonging to the Scottish National Party?
I wonder what happens to someone who has MTHFR when they undergo regular mild hyperbaric oxygen therapy.
Disease - DIS-EASE - is endogenous. How you eat, think and handle stress all invites cells to go rogue if it's bad.
Having the proper mindset, and thoughts can fix a lot issues. Get out to get some fresh air and sun also does wonders. An occasional fast (24 - 72 hours) is also good for the body.
I don't know about that. There are some things that a lack of methylation cannot cause
yet nothing about how to actually fix this issue...
u/mac1221
Curious re: ur thots?
@smartbaum sums it all up pretty well. Methylation is a poorly understood process and it seems that alternative health practitioners are just now jumping on the bandwagon seemingly without understanding the underlying science - just as our fellow anon has stated. Supplements alone cannot fix some of these underlying problems with mitochondrial dysfunction. Once again, light and other frequencies can have healthful or deleterious effects on how the body functions. It is hard to make money on sunlight. Thanks
Thx, Mac!
Seriously, how retarded are you? This is like saying that viruses and bacteria don’t exist.